TMPRSS12 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TMPRSS12 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TMPRSS12 at tissue level.

III. Associated gene sets

GO_0007339Biological processbinding of sperm to zona pellucida
GO_0016485Biological processprotein processing
GO_0007283Biological processspermatogenesis
GO_0001675Biological processacrosome assembly
GO_1902492Biological processpositive regulation of sperm capacitation
GO_0001669Cellular componentacrosomal vesicle
GO_0005886Cellular componentplasma membrane
GO_0004252Molecular functionserine-type endopeptidase activity

IV. Literature review

[source]
Gene nameTMPRSS12
Protein nameTransmembrane protease serine 12 (EC 3.4.21.-)
Transmembrane serine protease 12
Synonyms
DescriptionFUNCTION: Required for male fertility (By similarity). Plays a critical role in sperm capacitation and acrosome reactions during fertilization, and also plays a role in the regulation of proteins involved in spermatogenesis (By similarity). Regulates protein pathways that promote chromosomal synapsis formation, double-strand break repair, formation of the inner mitochondrial membrane cristae and apoptosis in developing sperm (By similarity). Required for normal sperm motility and binding to the zona pellucida, potentially via a role in ADAM3 protein maturation (By similarity). .

AccessionsQ86WS5
ENST00000398458.4
ENST00000551456.5
F8WBX2