TMEM68 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019432Biological processtriglyceride biosynthetic process
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0046027Molecular functionphospholipid:diacylglycerol acyltransferase activity

IV. Literature review

[source]
Gene nameTMEM68
Protein nameTransmembrane protein 68
DGAT1/2-independent enzyme synthesizing storage lipids (DIESL) (EC 2.3.1.-) (2-acylglycerol/1,2-diacylglycerol O-acyltransferase) (Monoacylglycerol/Diacylglycerol O-acyltransferase) (MGAT/DGAT) (EC 2.3.1.20, EC 2.3.1.22) (Transmembrane protein 68)
TMEM68 protein
Synonyms
DescriptionFUNCTION: Catalytic subunit of the alternative triglyceride biosynthesis pathway, which mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids . Synthesizes triacylglycerol at the expense of membrane phospholipids, such as phosphatidylcholine (PC) and its ether-linked form (ePC), thereby altering the composition of membranes . The alternative triglyceride biosynthesis pathway is probably required to provide the energy required for rapid growth when fuel sources are limiting . It maintains mitochondrial function during periods of extracellular lipid starvation . Can also use acyl-CoA as donor: acts as a acyl-CoA:monoacylglycerol acyltransferase (MGAT), but also shows acyl-CoA:diacylglycerol acyltransferase (DGAT) activity (By similarity). .

AccessionsENST00000517576.5
ENST00000522576.5 [Q96MH6-3]
ENST00000520061.5
ENST00000617782.4 [Q96MH6-1]
E5RHZ2
ENST00000523423.5
ENST00000521229.5 [Q96MH6-3]
ENST00000520414.5
H0YAX4
ENST00000522030.1
ENST00000519780.5
H0YC64
Q49A68
E5RHI6
ENST00000522470.1
H0YAY9
Q96MH6
E5RJN2
ENST00000519784.5
E5RJI9
ENST00000523073.5
ENST00000334667.6 [Q96MH6-2]
E5RGT2
E5RHU1
ENST00000434581.7 [Q96MH6-1]
ENST00000522090.5
E5RJ96