TKTL1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TKTL1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TKTL1 at tissue level.

III. Associated gene sets

GO_0006007Biological processglucose catabolic process
GO_0006772Biological processthiamine metabolic process
GO_0005829Cellular componentcytosol
GO_0030976Molecular functionthiamine pyrophosphate binding
GO_0004802Molecular functiontransketolase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameTKTL1
Protein nameTransketolase-like protein 1 (EC 2.2.1.1) (Transketolase 2) (TK 2) (Transketolase-related protein)
transketolase (EC 2.2.1.1)
SynonymsLL0XNC01-14B7.1-006
TKT2
TKR
LL0XNC01-14B7.1-005
DescriptionFUNCTION: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. .; FUNCTION: [Isoform 4]: During fetal neocortex development, may be essential to maintain the full number of basal radial glia (bRG). bRG are neural progenitor cells that undergo asymmetric divisions, generating a bRG (self-renewal) and a neuron, in contrast to basal intermediate progenitors (bIPs), which typically divide once to give rise to 2 neurons. bRG generate more cortical neurons over time than bIPs. .

AccessionsENST00000369912.2 [P51854-4]
F8WF97
A2ID96
H0Y808
ENST00000439635.5
ENST00000426989.5
A2ID95
ENST00000426203.5
ENST00000710264.1
P51854
ENST00000369915.8 [P51854-3]
A0AA34QVR6