I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 4 studies | 23% ± 5% | |
| oligodendrocyte precursor cell | 4 studies | 24% ± 7% | |
| endothelial cell | 3 studies | 17% ± 1% | |
| adipocyte | 3 studies | 20% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| astrocyte | 4 studies | 23% ± 5% | |
| oligodendrocyte precursor cell | 4 studies | 24% ± 7% | |
| endothelial cell | 3 studies | 17% ± 1% | |
| adipocyte | 3 studies | 20% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 28% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 2434.19 | 245 / 245 | 100% | 9.16 | 502 / 502 |
| brain | 100% | 2075.35 | 2641 / 2642 | 100% | 14.17 | 704 / 705 |
| kidney | 100% | 2598.28 | 89 / 89 | 100% | 12.31 | 899 / 901 |
| liver | 100% | 2281.41 | 226 / 226 | 100% | 6.75 | 404 / 406 |
| thymus | 100% | 2741.75 | 653 / 653 | 100% | 13.82 | 602 / 605 |
| breast | 100% | 3329.57 | 459 / 459 | 99% | 8.76 | 1111 / 1118 |
| skin | 100% | 1950.06 | 1807 / 1809 | 99% | 9.82 | 468 / 472 |
| pancreas | 100% | 1735.63 | 327 / 328 | 99% | 11.34 | 176 / 178 |
| adrenal gland | 100% | 3653.72 | 258 / 258 | 98% | 10.23 | 226 / 230 |
| bladder | 100% | 2122.52 | 21 / 21 | 98% | 5.98 | 492 / 504 |
| intestine | 100% | 1718.57 | 966 / 966 | 97% | 5.70 | 513 / 527 |
| lung | 100% | 2162.44 | 576 / 578 | 97% | 6.61 | 1123 / 1155 |
| stomach | 100% | 1544.85 | 359 / 359 | 95% | 4.91 | 272 / 286 |
| uterus | 100% | 2465.72 | 170 / 170 | 92% | 4.94 | 423 / 459 |
| esophagus | 100% | 1690.35 | 1443 / 1445 | 90% | 4.01 | 165 / 183 |
| ovary | 100% | 3016.45 | 180 / 180 | 85% | 3.74 | 366 / 430 |
| adipose | 100% | 3800.83 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2230.50 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.93 | 1 / 1 |
| blood vessel | 100% | 2417.32 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 98% | 1392.69 | 845 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 96% | 6.37 | 77 / 80 |
| muscle | 95% | 804.89 | 760 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 93% | 3.87 | 42 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 86% | 4.18 | 25 / 29 |
| peripheral blood | 75% | 1016.41 | 699 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006139 | Biological process | nucleobase-containing compound metabolic process |
| GO_0046104 | Biological process | thymidine metabolic process |
| GO_0071897 | Biological process | DNA biosynthetic process |
| GO_0046092 | Biological process | deoxycytidine metabolic process |
| GO_0009165 | Biological process | nucleotide biosynthetic process |
| GO_0009157 | Biological process | deoxyribonucleoside monophosphate biosynthetic process |
| GO_0043097 | Biological process | pyrimidine nucleoside salvage |
| GO_0005759 | Cellular component | mitochondrial matrix |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0019206 | Molecular function | nucleoside kinase activity |
| GO_0019136 | Molecular function | deoxynucleoside kinase activity |
| GO_0004797 | Molecular function | thymidine kinase activity |
| GO_0004137 | Molecular function | deoxycytidine kinase activity |
| GO_0005524 | Molecular function | ATP binding |
| Gene name | TK2 |
| Protein name | TK2 protein Thymidine kinase 2 isoform B Thymidine kinase 2, mitochondrial (EC 2.7.1.21) (2'-deoxyuridine kinase TK2) (EC 2.7.1.74) (Deoxycytidine kinase TK2) (EC 2.7.1.-) (Mt-TK) Thymidine kinase 2 Thymidine kinase 2, mitochondrial |
| Synonyms | |
| Description | FUNCTION: Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix . In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK . Widely used as target of antiviral and chemotherapeutic agents . . |
| Accessions | ENST00000620035.5 A0A7I2V471 A0A7I2YQY6 A0A7I2V3A3 A0A7I2V4A1 A0A7I2V5S4 ENST00000678861.1 ENST00000299697.12 A0A7I2V406 ENST00000679154.1 ENST00000567357.6 ENST00000677739.1 A0A7P0SB82 ENST00000544898.6 [O00142-1] ENST00000527800.6 [O00142-5] A0A0A0MSY7 ENST00000677555.1 [O00142-5] Q6I8R3 ENST00000451102.7 [O00142-2] A0A7I2V5P3 ENST00000678746.1 ENST00000563478.5 ENST00000417693 ENST00000676538.1 ENST00000569718.6 ENST00000527284.6 ENST00000677541.1 A5PLM0 O00142 ENST00000678190.1 ENST00000677319.1 ENST00000676904.1 ENST00000678015.1 [O00142-5] ENST00000561905.2 A0A7I2V408 ENST00000678219.1 A0A7I2V3V1 ENST00000525974.5 [O00142-5] ENST00000677420.1 [O00142-5] ENST00000676536.1 ENST00000677535.1 A0A7P0MLU2 A0A7I2V2L8 A4IF54 ENST00000562484.2 H3BP77 ENST00000545043.6 [O00142-3] ENST00000678099.1 ENST00000678314.1 A0A7P0PE46 A0A7I2V304 J3KS73 A0A7I2V465 J3KSZ2 ENST00000678297.1 [O00142-5] ENST00000677412.1 ENST00000677715.1 [O00142-5] ENST00000678205.1 ENST00000564917.5 A0A7I2V557 ENST00000677379.1 ENST00000417693.8 [O00142-4] H3BV57 J3QRP0 J3QL12 ENST00000563369.6 [O00142-5] |
