TIMD4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TIMD4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TIMD4 at tissue level.

III. Associated gene sets

GO_0043277Biological processapoptotic cell clearance
GO_0060097Biological processcytoskeletal rearrangement involved in phagocytosis, engulfment
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0001786Molecular functionphosphatidylserine binding

IV. Literature review

[source]
Gene nameTIMD4
Protein nameT-cell immunoglobulin and mucin domain-containing protein 4 (TIMD-4) (T-cell immunoglobulin mucin receptor 4) (TIM-4) (T-cell membrane protein 4)
T cell immunoglobulin and mucin domain containing 4
SynonymsTIM4
DescriptionFUNCTION: Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation. Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways (By similarity). Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells . Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion . Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of LKB1/PRKAA1 pathway in a phosphatidylserine-dependent mechanism (By similarity). .; FUNCTION: (Microbial infection) Plays a positive role in exosome-mediated trafficking of HIV-1 virus and its entry into immune cells. .

AccessionsENST00000406964.5
ENST00000407087.4 [Q96H15-2]
B5MCV9
ENST00000274532.7 [Q96H15-1]
Q96H15