TGM3 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of TGM3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	72%	6418.06	1298 / 1809	0%	0	0 / 472
esophagus	45%	72354.03	653 / 1445	11%	0.36	20 / 183
peripheral blood	22%	337.91	205 / 929	0%	0	0 / 0
liver	1%	4.61	2 / 226	9%	0.13	35 / 406
tonsil	0%	0	0 / 0	4%	0.06	2 / 45
prostate	3%	22.88	7 / 245	0%	0	0 / 502
uterus	2%	249.35	3 / 170	0%	0.00	1 / 459
ovary	2%	12.62	3 / 180	0%	0	0 / 430
intestine	1%	6.19	5 / 966	1%	0.03	5 / 527
spleen	1%	9.80	3 / 241	0%	0	0 / 0
adipose	1%	43.68	14 / 1204	0%	0	0 / 0
stomach	1%	238.34	4 / 359	0%	0	0 / 286
breast	1%	6.58	4 / 459	0%	0	0 / 1118
lung	1%	4.63	4 / 578	0%	0.00	2 / 1155
brain	1%	5.12	19 / 2642	0%	0	0 / 705
thymus	1%	4.42	4 / 653	0%	0	0 / 605
muscle	0%	27.00	4 / 803	0%	0	0 / 0
blood vessel	0%	7.71	6 / 1335	0%	0	0 / 0
adrenal gland	0%	3.67	1 / 258	0%	0	0 / 230
pancreas	0%	37.90	1 / 328	0%	0	0 / 178
abdomen	0%	0	0 / 0	0%	0	0 / 0
bladder	0%	0	0 / 21	0%	0	0 / 504
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
kidney	0%	0	0 / 89	0%	0	0 / 901
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0030216	Biological process	keratinocyte differentiation
GO_0031069	Biological process	hair follicle morphogenesis
GO_0031424	Biological process	keratinization
GO_0018149	Biological process	peptide cross-linking
GO_0036211	Biological process	protein modification process
GO_0005737	Cellular component	cytoplasm
GO_0032991	Cellular component	protein-containing complex
GO_0031234	Cellular component	extrinsic component of cytoplasmic side of plasma membrane
GO_0070062	Cellular component	extracellular exosome
GO_0003824	Molecular function	catalytic activity
GO_0005509	Molecular function	calcium ion binding
GO_0016746	Molecular function	acyltransferase activity
GO_0003810	Molecular function	protein-glutamine gamma-glutamyltransferase activity
GO_0005198	Molecular function	structural molecule activity

Gene name	TGM3
Protein name	Protein-glutamine gamma-glutamyltransferase E (EC 2.3.2.13) (Transglutaminase E) (TG(E)) (TGE) (TGase E) (Transglutaminase-3) (TGase-3) [Cleaved into: Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain; Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain] Alternative protein TGM3
Synonyms
Description	FUNCTION: Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath. .
Accessions	Q08188 L8E7G4 ENST00000381458.6

TGM3 report