TDRD6 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TDRD6 at tissue level.

III. Associated gene sets

GO_0030719Biological processP granule organization
GO_0007283Biological processspermatogenesis
GO_0034587Biological processpiRNA processing
GO_0033391Cellular componentchromatoid body
GO_0043186Cellular componentP granule
GO_0005737Cellular componentcytoplasm

IV. Literature review

[source]
Gene nameTDRD6
Protein nameTudor domain-containing protein 6 (Antigen NY-CO-45) (Cancer/testis antigen 41.2) (CT41.2)
Tudor domain containing 6
Synonyms
DescriptionFUNCTION: Tudor domain-containing protein involved in germ cell development, more specifically the formation of chromatoid body (during spermiogenesis), Balbiani body (during oogenesis), germ plasm (upon fertilization), and for proper miRNA expression and spliceosome maturation (By similarity). Essential for RNA-dependent helicase UPF1 localization to chromatoid body, for UPF1-UPF2 and UPF1-DDX4 interactions which are required for mRNA degradation, using the extended 3' UTR-triggered nonsense-mediated mRNA decay (NMD) pathway. Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through interaction with arginine N-methyltransferase PRMT5 and symmetrically arginine dimethylated SNRPB (small nuclear ribonucleoprotein-associated protein) (By similarity). .

AccessionsENST00000316081.11 [O60522-1]
A2IB45
ENST00000450697.1
H0Y590
O60522
ENST00000544460.5 [O60522-2]