TDRD12 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TDRD12 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TDRD12 at tissue level.

III. Associated gene sets

GO_0042078Biological processgerm-line stem cell division
GO_0009566Biological processfertilization
GO_0007283Biological processspermatogenesis
GO_0007140Biological processmale meiotic nuclear division
GO_0141007Biological processsiRNA-mediated retrotransposon silencing by heterochromatin formation
GO_0034587Biological processpiRNA processing
GO_0005575Cellular componentcellular_component
GO_1990923Cellular componentPET complex
GO_0016887Molecular functionATP hydrolysis activity
GO_0003724Molecular functionRNA helicase activity
GO_0003676Molecular functionnucleic acid binding
GO_0005524Molecular functionATP binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameTDRD12
Protein namePutative ATP-dependent RNA helicase TDRD12 (EC 3.6.4.13) (ES cell-associated transcript 8 protein) (Tudor domain-containing protein 12)
RNA helicase (EC 3.6.4.13)
Tudor domain containing 12
SynonymsECAT8
DescriptionFUNCTION: Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. .

AccessionsENST00000637289.1
A0A1W2PRK2
A0A2R8Y872
H3BU70
ENST00000421545.2 [Q587J7-2]
ENST00000564769.2
A0A1B0GU57
ENST00000639142.2
Q587J7
ENST00000444215.6 [Q587J7-1]
ENST00000647536.1