TCHH report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TCHH at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TCHH at tissue level.

III. Associated gene sets

GO_0045109Biological processintermediate filament organization
GO_0031424Biological processkeratinization
GO_0008150Biological processbiological_process
GO_0001533Cellular componentcornified envelope
GO_0005856Cellular componentcytoskeleton
GO_0005829Cellular componentcytosol
GO_0005509Molecular functioncalcium ion binding
GO_0046914Molecular functiontransition metal ion binding

IV. Literature review

[source]
Gene nameTCHH
Protein nameAlternative protein TCHH
Trichohyalin
TCHH protein
SynonymsTHL
THH
TRHY
DescriptionFUNCTION: Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation.

AccessionsL8ECD7
A2RRS3
ENST00000614923.2
Q07283