I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 6 studies | 28% ± 11% | |
| epithelial cell | 4 studies | 26% ± 9% | |
| adventitial cell | 4 studies | 26% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| fibroblast | 6 studies | 28% ± 11% | |
| epithelial cell | 4 studies | 26% ± 9% | |
| adventitial cell | 4 studies | 26% ± 3% |
Insufficient scRNA-seq data for expression of STEAP1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 2364.41 | 244 / 245 | 100% | 343.38 | 501 / 502 |
| intestine | 97% | 655.14 | 936 / 966 | 92% | 45.66 | 487 / 527 |
| esophagus | 95% | 614.40 | 1374 / 1445 | 93% | 49.76 | 170 / 183 |
| lung | 95% | 910.61 | 547 / 578 | 89% | 56.03 | 1029 / 1155 |
| stomach | 85% | 436.64 | 306 / 359 | 92% | 45.92 | 263 / 286 |
| bladder | 95% | 949.90 | 20 / 21 | 81% | 34.62 | 408 / 504 |
| breast | 99% | 1135.68 | 456 / 459 | 74% | 25.90 | 829 / 1118 |
| ovary | 87% | 350.17 | 157 / 180 | 80% | 24.57 | 342 / 430 |
| liver | 96% | 959.81 | 217 / 226 | 62% | 29.48 | 250 / 406 |
| pancreas | 59% | 179.83 | 193 / 328 | 93% | 48.16 | 166 / 178 |
| uterus | 67% | 269.68 | 114 / 170 | 77% | 28.74 | 355 / 459 |
| skin | 69% | 2265.94 | 1245 / 1809 | 58% | 16.24 | 274 / 472 |
| adipose | 100% | 1408.68 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 93% | 34.23 | 42 / 45 |
| blood vessel | 90% | 591.29 | 1201 / 1335 | 0% | 0 | 0 / 0 |
| thymus | 72% | 312.98 | 470 / 653 | 6% | 1.22 | 39 / 605 |
| kidney | 34% | 101.10 | 30 / 89 | 25% | 4.91 | 223 / 901 |
| spleen | 55% | 118.88 | 132 / 241 | 0% | 0 | 0 / 0 |
| heart | 40% | 185.68 | 348 / 861 | 0% | 0 | 0 / 0 |
| adrenal gland | 24% | 58.31 | 61 / 258 | 4% | 2.30 | 10 / 230 |
| brain | 5% | 9.74 | 131 / 2642 | 15% | 3.79 | 108 / 705 |
| lymph node | 0% | 0 | 0 / 0 | 17% | 3.19 | 5 / 29 |
| peripheral blood | 12% | 65.62 | 116 / 929 | 0% | 0 | 0 / 0 |
| muscle | 7% | 21.30 | 55 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 5% | 0.58 | 4 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0005911 | Cellular component | cell-cell junction |
| GO_0010008 | Cellular component | endosome membrane |
| GO_0005768 | Cellular component | endosome |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0052851 | Molecular function | ferric-chelate reductase (NADPH) activity |
| GO_0020037 | Molecular function | heme binding |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | STEAP1 |
| Protein name | STEAP1 protein (Six-transmembrane epithelial antigen of prostate 1) STEAP family member 1 |
| Synonyms | STEAP PRSS24 |
| Description | FUNCTION: Does not function as a metalloreductase due to the absence of binding sites for the electron-donating substrate NADPH. Promotes Fe(3+) reduction when fused to the NADPH-binding domain of STEAP4. . |
| Accessions | ENST00000412573.1 Q9UHE8 H7C0D8 ENST00000297205.7 |
