ST8SIA3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097503Biological processsialylation
GO_0001574Biological processganglioside biosynthetic process
GO_0006688Biological processglycosphingolipid biosynthetic process
GO_0009100Biological processglycoprotein metabolic process
GO_0009311Biological processoligosaccharide metabolic process
GO_0006491Biological processN-glycan processing
GO_0006486Biological processprotein glycosylation
GO_0000139Cellular componentGolgi membrane
GO_0003828Molecular functionalpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
GO_0042802Molecular functionidentical protein binding
GO_0033691Molecular functionsialic acid binding

IV. Literature review

[source]
Gene nameST8SIA3
Protein nameST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3 (EC 2.4.3.-) (Alpha-2,8-sialyltransferase 8C) (Alpha-2,8-sialyltransferase III) (Ganglioside GD3 synthase ST8SIA3) (EC 2.4.3.8) (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3) (Sia-a2,3-Gal-b1,4-Glc-NAc-R:a2,8-sialyltransferase) (hST8Sia III) (Sialyltransferase 8C) (SIAT8-C) (Sialyltransferase St8Sia III) (ST8SiaIII)
SynonymsSIAT8C
DescriptionFUNCTION: Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an acceptor, such as N-linked oligosaccharides of glycoproteins and glycolipids through alpha-2,8-linkages . Forms oligosialic and polysialic acid on various sialylated N-acetyllactosamine oligosaccharides of glycoproteins, including FETUB N-glycans, a2-HS-glycoprotein (AHSG) and alpha 2,3-sialylated glycosphingolipids, such as alpha 2,3-sialylparagloboside and ganglioside GM3 and to a lesser extent NCAM1 N-glycans . However, it is much more specific to N-linked oligosaccharides of glycoproteins than glycosphingolipids (By similarity). 2,3-sialylparagloboside serves as the best acceptor substrate among the glycolipids (By similarity). alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-6S-D-GlcNAc and monosialyl and disialyl N-acetyllactosamines are the best acceptor substrates among glycoproteins . May plays critical role in the striatum by mediating the formation of disialylated and trisialylated terminal glycotopes on N- and O-glycans of specific striatal proteins, regulating their distribution in lipid rafts, affecting their interaction with other binding partners, and subsequently modulating striatal functions (By similarity). .

AccessionsO43173
ENST00000324000.4
K7EQB3
ENST00000586360.1