ST6GALNAC5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009312Biological processoligosaccharide biosynthetic process
GO_0001574Biological processganglioside biosynthetic process
GO_0006688Biological processglycosphingolipid biosynthetic process
GO_0009311Biological processoligosaccharide metabolic process
GO_0006486Biological processprotein glycosylation
GO_0000139Cellular componentGolgi membrane
GO_0001665Molecular functionalpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
GO_0008373Molecular functionsialyltransferase activity

IV. Literature review

[source]
Gene nameST6GALNAC5
Protein nameSiat7e
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (EC 2.4.99.-) (GD1 alpha synthase) (GalNAc alpha-2,6-sialyltransferase V) (ST6GalNAc V) (ST6GalNAcV) (Sialyltransferase 7E) (SIAT7-E)
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SynonymsSIAT7E
DescriptionFUNCTION: Predominantly catalyzes the biosynthesis of ganglioside GD1alpha from GM1b in the brain, by transferring the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of GM1b . GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Also shows activity towards sialyl Lc4Cer (N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine) generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen . .

AccessionsV5N4G2
ENST00000477717.6
ENST00000318803.6
Q9BVH7
F2Z2C8