SPRED3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SPRED3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPRED3 at tissue level.

III. Associated gene sets

GO_1902747Biological processnegative regulation of lens fiber cell differentiation
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0010719Biological processnegative regulation of epithelial to mesenchymal transition
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0043409Biological processnegative regulation of MAPK cascade
GO_0005886Cellular componentplasma membrane
GO_0019901Molecular functionprotein kinase binding

IV. Literature review

[source]
Gene nameSPRED3
Protein nameSprouty-related, EVH1 domain-containing protein 3 (Spred-3)
HCG1647763 (Sprouty related EVH1 domain containing 3)
Sprouty related EVH1 domain containing 3
Sprouty-related, EVH1 domain containing 3
SynonymsEVE-3
hCG_1647763
DescriptionFUNCTION: Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). .

AccessionsB9EKV1
K7EPT9
ENST00000586301.6 [Q2MJR0-1]
ENST00000586958.1
ENST00000587013.6
K7EPU5
K7EKP4
Q2MJR0
ENST00000691638.1 [Q2MJR0-1]
ENST00000587947.5
ENST00000338502.8 [Q2MJR0-1]