SPIRE2 | OmnibusX

Name	Number of supported studies	Average coverage
brain	4 studies	26% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	98%	2165.68	2598 / 2642	97%	8.09	682 / 705
liver	96%	603.68	217 / 226	94%	6.54	381 / 406
prostate	93%	946.09	228 / 245	93%	4.32	465 / 502
intestine	78%	1662.30	755 / 966	98%	23.25	516 / 527
thymus	100%	1465.81	652 / 653	75%	4.39	451 / 605
adrenal gland	84%	352.02	216 / 258	90%	8.34	207 / 230
stomach	76%	1078.89	274 / 359	95%	19.28	273 / 286
lung	81%	457.93	470 / 578	82%	7.31	951 / 1155
bladder	71%	1004.81	15 / 21	91%	15.88	461 / 504
breast	76%	354.75	349 / 459	85%	5.26	953 / 1118
uterus	58%	306.05	98 / 170	92%	8.41	421 / 459
kidney	92%	510.58	82 / 89	56%	3.17	506 / 901
skin	63%	248.13	1131 / 1809	85%	4.97	401 / 472
esophagus	64%	275.42	930 / 1445	81%	9.19	149 / 183
ovary	68%	314.23	122 / 180	72%	4.46	309 / 430
pancreas	43%	150.34	140 / 328	92%	12.84	164 / 178
ureter	0%	0	0 / 0	100%	30.96	1 / 1
eye	0%	0	0 / 0	96%	7.12	77 / 80
tonsil	0%	0	0 / 0	73%	4.66	33 / 45
adipose	51%	181.39	617 / 1204	0%	0	0 / 0
spleen	34%	101.67	82 / 241	0%	0	0 / 0
lymph node	0%	0	0 / 0	7%	1.01	2 / 29
heart	6%	17.24	55 / 861	0%	0	0 / 0
peripheral blood	2%	4.98	15 / 929	0%	0	0 / 0
blood vessel	1%	3.97	19 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0046907	Biological process	intracellular transport
GO_0030041	Biological process	actin filament polymerization
GO_0045010	Biological process	actin nucleation
GO_0051639	Biological process	actin filament network formation
GO_0048193	Biological process	Golgi vesicle transport
GO_0030036	Biological process	actin cytoskeleton organization
GO_0016192	Biological process	vesicle-mediated transport
GO_0015031	Biological process	protein transport
GO_0051295	Biological process	establishment of meiotic spindle localization
GO_0036089	Biological process	cleavage furrow formation
GO_0070649	Biological process	formin-nucleated actin cable assembly
GO_2000781	Biological process	positive regulation of double-strand break repair
GO_0040038	Biological process	polar body extrusion after meiotic divisions
GO_0005856	Cellular component	cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0005938	Cellular component	cell cortex
GO_0032154	Cellular component	cleavage furrow
GO_0030659	Cellular component	cytoplasmic vesicle membrane
GO_0008017	Molecular function	microtubule binding
GO_0003779	Molecular function	actin binding

Gene name	SPIRE2
Protein name	Protein spire homolog 2 (Spir-2) Spire type actin nucleation factor 2
Synonyms	KIAA1832 SPIR2
Description	FUNCTION: Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament . Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis . Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis . Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage . .
Accessions	H3BV39 ENST00000378247.8 [Q8WWL2-1] Q8WWL2 ENST00000393062.6 [Q8WWL2-2] H3BV74 ENST00000563972.1 ENST00000566337.5

SPIRE2 report