SPAM1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SPAM1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPAM1 at tissue level.

III. Associated gene sets

GO_0005975Biological processcarbohydrate metabolic process
GO_0007339Biological processbinding of sperm to zona pellucida
GO_0007155Biological processcell adhesion
GO_0007342Biological processfusion of sperm to egg plasma membrane involved in single fertilization
GO_0030214Biological processhyaluronan catabolic process
GO_0098552Cellular componentside of membrane
GO_0001669Cellular componentacrosomal vesicle
GO_0005886Cellular componentplasma membrane
GO_0004415Molecular functionhyalurononglucosaminidase activity

IV. Literature review

[source]
Gene nameSPAM1
Protein nameHyaluronidase (EC 3.2.1.35)
Sperm adhesion molecule 1
Hyaluronidase PH-20 (Hyal-PH20) (EC 3.2.1.35) (Hyaluronoglucosaminidase PH-20) (Sperm adhesion molecule 1) (Sperm surface protein PH-20)
SynonymsHEL-S-96n
PH20
tcag7.49
HYAL3
hCG_32922
DescriptionFUNCTION: Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid. .

AccessionsQ5D1J4
ENST00000223028.11 [P38567-1]
ENST00000402183.3 [P38567-2]
C9J2X5
ENST00000413927.5
ENST00000439500.5 [P38567-1]
ENST00000682466.1 [P38567-1]
P38567
ENST00000340011.9 [P38567-2]
ENST00000460182.5 [P38567-1]