SPAAR report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPAAR at tissue level.

III. Associated gene sets

GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0043416Biological processregulation of skeletal muscle tissue regeneration
GO_0071230Biological processcellular response to amino acid stimulus
GO_0046611Cellular componentlysosomal proton-transporting V-type ATPase complex
GO_0031902Cellular componentlate endosome membrane
GO_0005765Cellular componentlysosomal membrane

IV. Literature review

[source]
Gene nameSPAAR
Protein nameSmall regulatory polypeptide of amino acid response
SynonymsLINC00961
SPAR
DescriptionFUNCTION: [Isoform 2]: Negative regulator of amino acid sensing and mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels and amino acids . Negatively regulates mTORC1 activation by inhibiting recruitment of mTORC1 to lysosomes upon stimulation with amino acids: acts by promoting the formation of a tightly bound supercomplex composed of the lysosomal V-ATPase, Ragulator and Rag GTPases, preventing recruitment of mTORC1 . Acts as a regulator of muscle regeneration following injury by regulating mTORC1 activation (By similarity). .

AccessionsENST00000636776.1 [A0A1B0GVQ0-2]
ENST00000638062.1 [A0A1B0GVQ0-2]
ENST00000443779.3 [A0A1B0GVQ0-2]
A0A1B0GVQ0