SLFN14 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SLFN14 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLFN14 at tissue level.

III. Associated gene sets

GO_0016075Biological processrRNA catabolic process
GO_0036345Biological processplatelet maturation
GO_0006402Biological processmRNA catabolic process
GO_0071287Biological processcellular response to manganese ion
GO_0071286Biological processcellular response to magnesium ion
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0043022Molecular functionribosome binding
GO_0004521Molecular functionRNA endonuclease activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameSLFN14
Protein nameProtein SLFN14 [Cleaved into: C-terminally truncated SLFN14 endoribonuclease (EC 3.1.-.-) (Schlafen family member 14)]
Synonyms
DescriptionFUNCTION: [Protein SLFN14]: Shows no ribosome-associated and endoribonuclease activities. .; FUNCTION: [C-terminally truncated SLFN14 endoribonuclease]: Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs . May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable). Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner (By similarity). Involved in correct maturation of megakaryocytes and especially important for proplatelet extension. .

AccessionsENST00000415846.3 [P0C7P3-1]
ENST00000674182.1 [P0C7P3-1]
P0C7P3