I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 17 studies | 42% ± 14% | |
| retinal pigment epithelial cell | 3 studies | 25% ± 9% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| astrocyte | 17 studies | 42% ± 14% | |
| retinal pigment epithelial cell | 3 studies | 25% ± 9% |
Insufficient scRNA-seq data for expression of SLCO1C1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 97% | 1416.72 | 2555 / 2642 | 99% | 21.04 | 695 / 705 |
| thymus | 85% | 157.13 | 553 / 653 | 32% | 0.55 | 191 / 605 |
| breast | 51% | 88.21 | 233 / 459 | 2% | 0.03 | 25 / 1118 |
| adipose | 52% | 88.26 | 629 / 1204 | 0% | 0 | 0 / 0 |
| kidney | 2% | 1.78 | 2 / 89 | 33% | 0.67 | 298 / 901 |
| heart | 27% | 32.41 | 229 / 861 | 0% | 0 | 0 / 0 |
| skin | 3% | 3.74 | 62 / 1809 | 14% | 0.61 | 66 / 472 |
| blood vessel | 17% | 21.87 | 222 / 1335 | 0% | 0 | 0 / 0 |
| esophagus | 10% | 11.46 | 147 / 1445 | 5% | 0.08 | 9 / 183 |
| adrenal gland | 0% | 0.30 | 1 / 258 | 13% | 0.26 | 29 / 230 |
| intestine | 11% | 11.78 | 106 / 966 | 1% | 0.01 | 6 / 527 |
| lung | 8% | 9.29 | 48 / 578 | 2% | 0.11 | 27 / 1155 |
| pancreas | 1% | 0.92 | 3 / 328 | 9% | 0.14 | 16 / 178 |
| prostate | 7% | 9.51 | 17 / 245 | 0% | 0.00 | 1 / 502 |
| bladder | 5% | 4.10 | 1 / 21 | 1% | 0.04 | 7 / 504 |
| stomach | 3% | 3.81 | 12 / 359 | 2% | 0.04 | 7 / 286 |
| eye | 0% | 0 | 0 / 0 | 5% | 0.09 | 4 / 80 |
| uterus | 0% | 0 | 0 / 170 | 2% | 0.06 | 8 / 459 |
| ovary | 1% | 0.63 | 1 / 180 | 1% | 0.02 | 4 / 430 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.05 | 3 / 406 |
| muscle | 0% | 0.49 | 3 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0015721 | Biological process | bile acid and bile salt transport |
| GO_0006811 | Biological process | monoatomic ion transport |
| GO_2000611 | Biological process | positive regulation of thyroid hormone generation |
| GO_0070327 | Biological process | thyroid hormone transport |
| GO_0043252 | Biological process | sodium-independent organic anion transport |
| GO_0055085 | Biological process | transmembrane transport |
| GO_0150104 | Biological process | transport across blood-brain barrier |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016323 | Cellular component | basolateral plasma membrane |
| GO_0015125 | Molecular function | bile acid transmembrane transporter activity |
| GO_0015349 | Molecular function | thyroid hormone transmembrane transporter activity |
| GO_0008514 | Molecular function | organic anion transmembrane transporter activity |
| GO_0015347 | Molecular function | sodium-independent organic anion transmembrane transporter activity |
| Gene name | SLCO1C1 |
| Protein name | Solute carrier organic anion transporter family member 1C1 (Organic anion transporter 1C1) (OATP1C1) (Organic anion transporter F) (OATP-F) (Organic anion transporter polypeptide-related protein 5) (OAT-RP-5) (OATP-RP5) (Organic anion-transporting polypeptide 14) (OATP-14) (Solute carrier family 21 member 14) (Thyroxine transporter) Solute carrier organic anion transporter family member 1C1 Alternative protein SLCO1C1 |
| Synonyms | SLC21A14 OATP14 OATPF OATP1C1 |
| Description | FUNCTION: Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones L-thyroxine (T4), L-thyroxine sulfate (T4S), and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) at the plasma membrane . Regulates T4 levels in different brain regions by transporting T4, and also by serving as an export pump for T4S, which is a source of T4 after hydrolysis by local sulfatases . Increases the access of these substrates to the intracellular sites where they are metabolized by the deiodinases . Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)), estrone-3-sulfate (E1S) and sulfobromophthalein (BSP) are transported with much lower efficiency . Transports T4 and E1S in a pH-insensitive manner . Facilitates the transport of thyroid hormones across the blood-brain barrier and into glia and neuronal cells in the brain . . |
| Accessions | ENST00000540354.5 [Q9NYB5-2] ENST00000539415.5 L8EC48 F5H6S4 ENST00000545102.1 [Q9NYB5-4] ENST00000266509.7 [Q9NYB5-1] Q9NYB5 ENST00000545604.5 [Q9NYB5-3] |
