SLCO1B3-SLCO1B7 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SLCO1B3-SLCO1B7 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLCO1B3-SLCO1B7 at tissue level.

III. Associated gene sets

GO_0055085Biological processtransmembrane transport
GO_0006869Biological processlipid transport
GO_0030868Cellular componentsmooth endoplasmic reticulum membrane
GO_0005886Cellular componentplasma membrane
GO_0004867Molecular functionserine-type endopeptidase inhibitor activity
GO_0022857Molecular functiontransmembrane transporter activity

IV. Literature review

[source]
Gene nameSLCO1B3-SLCO1B7
Protein nameSLCO1B3-SLCO1B7 readthrough transcript protein (Liver specific transporter-3 transmembrane 12) (LST-3TM12) (Organic anion transporting polypeptide 1B3-1B7) (OATP1B3-1B7) (Solute carrier organic anion transporter family member 1B3-1B7) (SLCO1B3-SLCO1B7)
Solute carrier organic anion transporter family member
SynonymsLST3
DescriptionFUNCTION: Mediates the Na(+)-independent uptake of organic anions . Transports the conjugated steroids 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate) or E2G) and dehydroepiandrosterone 3-sulfate (DHEAS) at the smooth endoplasmic reticulum membrane (SER), granting access to metabolizing enzymes . Contributes to the metabolism of bile acids such as taurocholate (cholyltaurine) and lithocholate, by functioning as a doorway between SER and cytosol, thereby decreasing their circulating levels and protecting the organism from their detergent properties . Regulates access or exit of drugs to the SER lumen . .

AccessionsQ5JAR5
ENST00000381541.7 [F5H094-1]
F5H094