SLCO1B1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLCO1B1 at tissue level.

III. Associated gene sets

GO_0015721Biological processbile acid and bile salt transport
GO_0006811Biological processmonoatomic ion transport
GO_0043252Biological processsodium-independent organic anion transport
GO_0006805Biological processxenobiotic metabolic process
GO_0015732Biological processprostaglandin transport
GO_0070327Biological processthyroid hormone transport
GO_0042167Biological processheme catabolic process
GO_0015711Biological processorganic anion transport
GO_0055085Biological processtransmembrane transport
GO_0016323Cellular componentbasolateral plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0009925Cellular componentbasal plasma membrane
GO_0016020Cellular componentmembrane
GO_0015132Molecular functionprostaglandin transmembrane transporter activity
GO_0015125Molecular functionbile acid transmembrane transporter activity
GO_0015349Molecular functionthyroid hormone transmembrane transporter activity
GO_0008514Molecular functionorganic anion transmembrane transporter activity
GO_0015347Molecular functionsodium-independent organic anion transmembrane transporter activity

IV. Literature review

[source]
Gene nameSLCO1B1
Protein nameOrganic anion transporting polypeptide
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) (Liver-specific organic anion transporter 1) (LST-1) (OATP-C) (Organic anion transporter SLC21A6) (Sodium-independent organic anion-transporting polypeptide 2) (OATP-2) (Solute carrier family 21 member 6)
Solute carrier organic anion transporter family member
SynonymsOATP1B1
LST1
OATP2
SLC21A6
OATPC
DescriptionFUNCTION: Mediates the Na(+)-independent uptake of organic anions . Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (dehydroepiandrosterone 3-sulfate, 17-beta-glucuronosyl estradiol, and estrone 3-sulfate), as well as eicosanoids (prostaglandin E2, thromboxane B2, leukotriene C4, and leukotriene E4), and thyroid hormones (T4/L-thyroxine, and T3/3,3',5'-triiodo-L-thyronine) . Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop . Involved in the clearance of endogenous and exogenous substrates from the liver . Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition . May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can transport HMG-CoA reductase inhibitors (also known as statins), such as pravastatin and pitavastatin, a clinically important class of hypolipidemic drugs . May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drug methotrexate . May also transport antihypertension agents, such as the angiotensin-converting enzyme (ACE) inhibitor prodrug enalapril, and the highly selective angiotensin II AT1-receptor antagonist valsartan, in the liver . Shows a pH-sensitive substrate specificity towards prostaglandin E2 and T4 which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment . Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions . .

AccessionsQ05CV5
Q0VGM0
Q7Z4M3
Q9Y6L6
K4P1Y1
Q6NSF9
ENST00000256958.3
K4P403
K4PF41