SLCO1A2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015721Biological processbile acid and bile salt transport
GO_0006811Biological processmonoatomic ion transport
GO_0043252Biological processsodium-independent organic anion transport
GO_0015695Biological processorganic cation transport
GO_0006805Biological processxenobiotic metabolic process
GO_0015711Biological processorganic anion transport
GO_0055085Biological processtransmembrane transport
GO_0016324Cellular componentapical plasma membrane
GO_0009925Cellular componentbasal plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0015125Molecular functionbile acid transmembrane transporter activity
GO_0008514Molecular functionorganic anion transmembrane transporter activity
GO_0015347Molecular functionsodium-independent organic anion transmembrane transporter activity
GO_0015101Molecular functionorganic cation transmembrane transporter activity
GO_0022857Molecular functiontransmembrane transporter activity

IV. Literature review

[source]
Gene nameSLCO1A2
Protein nameSolute carrier organic anion transporter family member 1A2
Solute carrier organic anion transporter family member 1A2 (OATP1A2) (OATP-A) (Organic anion-transporting polypeptide 1) (OATP-1) (Sodium-independent organic anion transporter) (Solute carrier family 21 member 3)
Solute carrier organic anion transporter family member
SynonymsOATP1A2
SLC21A3
OATP1
OATP
DescriptionFUNCTION: Na(+)-independent transporter that mediates the cellular uptake of a broad range of organic anions such as the endogenous bile salts cholate and deoxycholate, either in their unconjugated or conjugated forms (taurocholate and glycocholate), at the plasmam membrane . Responsible for intestinal absorption of bile acids (By similarity). Transports dehydroepiandrosterone 3-sulfate (DHEAS), a major circulating steroid secreted by the adrenal cortex, as well as estrone 3-sulfate and 17beta-estradiol 17-O-(beta-D-glucuronate) . Mediates apical uptake of all-trans-retinol (atROL) across human retinal pigment epithelium, which is essential to maintaining the integrity of the visual cycle and thus vision . Involved in the uptake of clinically used drugs . Capable of thyroid hormone transport (both T3 or 3,3',5'-triiodo-L-thyronine, and T4 or L-tyroxine) . Also transports prostaglandin E2 . Plays roles in blood-brain and -cerebrospinal fluid barrier transport of organic anions and signal mediators, and in hormone uptake by neural cells (By similarity). May also play a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons . May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drugs methotrexate and paclitaxel . Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment . Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions . May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). .

AccessionsC9JTF6
C9IYW8
B4DJE6
ENST00000416627.1
ENST00000422327.5
ENST00000445053.1
P46721
C9JCA7
Q8IV69
ENST00000435179.5
ENST00000544020.5
ENST00000544290.5
F5H060
F5GXY6
ENST00000413682.5
C9JG34
ENST00000450590.5
ENST00000453443.5
C9JUW6
C9JSB7
C9JHU9
C9K059
ENST00000683939.1 [P46721-1]
ENST00000307378.10 [P46721-1]
ENST00000458504.5
ENST00000421287.5