SLC8B1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051480Biological processregulation of cytosolic calcium ion concentration
GO_0050796Biological processregulation of insulin secretion
GO_0006811Biological processmonoatomic ion transport
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0051560Biological processmitochondrial calcium ion homeostasis
GO_0086036Biological processregulation of cardiac muscle cell membrane potential
GO_2001256Biological processregulation of store-operated calcium entry
GO_0099093Biological processcalcium export from the mitochondrion
GO_0006851Biological processmitochondrial calcium ion transmembrane transport
GO_1901623Biological processregulation of lymphocyte chemotaxis
GO_0035725Biological processsodium ion transmembrane transport
GO_0042593Biological processglucose homeostasis
GO_0005886Cellular componentplasma membrane
GO_0030061Cellular componentmitochondrial crista
GO_0016020Cellular componentmembrane
GO_0031966Cellular componentmitochondrial membrane
GO_0042383Cellular componentsarcolemma
GO_0005743Cellular componentmitochondrial inner membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0086038Molecular functioncalcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential
GO_0015368Molecular functioncalcium:monoatomic cation antiporter activity
GO_0005432Molecular functioncalcium:sodium antiporter activity

IV. Literature review

[source]
Gene nameSLC8B1
Protein nameMitochondrial sodium/calcium exchanger protein (Na(+)/K(+)/Ca(2+)-exchange protein 6) (Sodium/calcium exchanger protein, mitochondrial) (Sodium/potassium/calcium exchanger 6) (Solute carrier family 24 member 6) (Solute carrier family 8 member B1)
Solute carrier family 8 member B1
SynonymsNCLX
NCKX6
SLC24A6
DescriptionFUNCTION: Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion . Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses . Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity . Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange . In contrast to other members of the family its function is independent of K(+) . .

AccessionsENST00000550672.5
ENST00000202831.7 [Q6J4K2-1]
F8VTU4
H0YI75
ENST00000549069.5
F8VW44
ENST00000550047.5
ENST00000549181.5
A0A0B4J252
F8VWW9
F8W134
ENST00000546737.5 [Q6J4K2-2]
ENST00000549372.1
ENST00000680972.1 [Q6J4K2-1]
ENST00000552014.5 [Q6J4K2-1]
F8VR99
ENST00000552613.1
ENST00000548186.5
ENST00000549605.5
Q6J4K2