SLC6A5 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SLC6A5 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC6A5 at tissue level.

III. Associated gene sets

GO_0060012Biological processsynaptic transmission, glycinergic
GO_1903804Biological processglycine import across plasma membrane
GO_0007268Biological processchemical synaptic transmission
GO_0035725Biological processsodium ion transmembrane transport
GO_0006836Biological processneurotransmitter transport
GO_0005768Cellular componentendosome
GO_0042734Cellular componentpresynaptic membrane
GO_0031045Cellular componentdense core granule
GO_0098690Cellular componentglycinergic synapse
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0015375Molecular functionglycine:sodium symporter activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameSLC6A5
Protein nameTransporter
Solute carrier family 6 member 5
Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5)
SLC6A5 protein
SynonymsNET1
GLYT2
DescriptionFUNCTION: Sodium- and chloride-dependent glycine transporter . Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals . May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses . .; FUNCTION: [Isoform 2]: Lacks sodium- and chloride-dependent glycine transporter activity. .; FUNCTION: [Isoform 3]: Lacks sodium- and chloride-dependent glycine transporter activity. .

AccessionsQ9Y345
ENST00000298923.11
Q4VAM6
J3KNC4
ENST00000525748.6 [Q9Y345-1]
Q4VAM5
Q4VAM4