SLC4A11 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC4A11 at tissue level.

III. Associated gene sets

GO_0042044Biological processfluid transport
GO_0071476Biological processcellular hypotonic response
GO_0035445Biological processborate transmembrane transport
GO_0055085Biological processtransmembrane transport
GO_0046713Biological processborate transport
GO_2000739Biological processregulation of mesenchymal stem cell differentiation
GO_0051881Biological processregulation of mitochondrial membrane potential
GO_0006833Biological processwater transport
GO_0006820Biological processmonoatomic anion transport
GO_0034599Biological processcellular response to oxidative stress
GO_0006814Biological processsodium ion transport
GO_0030003Biological processintracellular monoatomic cation homeostasis
GO_0050801Biological processmonoatomic ion homeostasis
GO_0015701Biological processbicarbonate transport
GO_0035725Biological processsodium ion transmembrane transport
GO_1902600Biological processproton transmembrane transport
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0012506Cellular componentvesicle membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0005272Molecular functionsodium channel activity
GO_0015078Molecular functionproton transmembrane transporter activity
GO_0015293Molecular functionsymporter activity
GO_0015252Molecular functionproton channel activity
GO_0015106Molecular functionbicarbonate transmembrane transporter activity
GO_0046715Molecular functionactive borate transmembrane transporter activity
GO_0005372Molecular functionwater transmembrane transporter activity
GO_0046983Molecular functionprotein dimerization activity
GO_0005452Molecular functionsolute:inorganic anion antiporter activity
GO_0022857Molecular functiontransmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC4A11
Protein nameSolute carrier family 4 member 11 (Solute carrier family 4, sodium bicarbonate transporter-like, member 11, isoform CRA_d)
Solute carrier family 4 sodium borate transporter member 11
Solute carrier family 4 member 11 (Sodium borate cotransporter 1) (NaBC1)
Solute carrier family 4 member 11
SynonymshCG_39254
BTR1
DescriptionFUNCTION: Multifunctional transporter with an impact in cell morphology and differentiation. In the presence of borate B(OH)4(-), acts as a voltage-dependent electrogenic Na(+)-coupled B(OH)4(-) cotransporter controlling boron homeostasis . At early stages of stem cell differentiation, participates in synergy with ITGA5-ITGB1 and ITGAV-ITGB3 integrins and BMPR1A to promote cell adhesion and contractility that drives differentiation toward osteogenic commitment while inhibiting adipogenesis (By similarity). In the absence of B(OH)4(-), acts as a Na(+)-coupled OH(-) or H(+) permeable channel with implications in cellular redox balance . Regulates the oxidative stress response in corneal endothelium by enhancing antioxidant defenses and protecting cells from reactive oxygen species . In response to hypo-osmotic challenge, also acts as a water permeable channel at the basolateral cell membrane of corneal endothelial cells and facilitates transendothelial fluid reabsorption in the aqueous humor . In the presence of ammonia, acts as an electrogenic NH3/H(+) cotransporter and may play a role in ammonia transport and reabsorption in renal Henle's loop epithelium . .

AccessionsR9UMG9
R9UQ58
ENST00000380056.7 [Q8NBS3-1]
ENST00000642402.1 [Q8NBS3-3]
ENST00000644692.1
ENST00000647296.1
ENST00000644862.1
ENST00000645524.1
R9UQR4
A0A2R8YEG3
R9UQ64
ENST00000437836.2
R9UQ67
A0A2R8Y7S1
A0A2R8YFD9
ENST00000474451.5
V9GXZ2
A0A2R8Y4A6
ENST00000380059.7 [Q8NBS3-4]
V9GYK6
A0A2R8Y6X5
Q8NBS3
ENST00000644011.1
R9UNY3
R9UQ62