SLC47A2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SLC47A2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC47A2 at tissue level.

III. Associated gene sets

GO_1902600Biological processproton transmembrane transport
GO_1990961Biological processxenobiotic detoxification by transmembrane export across the plasma membrane
GO_0015695Biological processorganic cation transport
GO_0055085Biological processtransmembrane transport
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0042910Molecular functionxenobiotic transmembrane transporter activity
GO_0015297Molecular functionantiporter activity
GO_0140968Molecular functionpolyspecific organic cation:proton antiporter activity
GO_0015101Molecular functionorganic cation transmembrane transporter activity
GO_0022857Molecular functiontransmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC47A2
Protein nameMultidrug and toxin extrusion protein 2 (MATE-2) (hMATE-2) (Kidney-specific H(+)/organic cation antiporter) (Solute carrier family 47 member 2)
Multidrug and toxin extrusion protein 2
SynonymsMATE2
DescriptionFUNCTION: Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP+), the platinum-based drug oxaliplatin or weak bases that are positively charged at physiological pH, cimetidine, the platinum-based drugs cisplatin and oxaliplatin or the antidiabetic drug metformin. Mediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney. .; FUNCTION: [Isoform 6]: Non-functional protein. .

AccessionsENST00000350657.9 [Q86VL8-4]
ENST00000433844
Q86VL8
ENST00000433844.4 [Q86VL8-3]
ENST00000574239.5 [Q86VL8-6]
ENST00000325411.9 [Q86VL8-1]
C9JAE6