SLC46A3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034486Biological processvacuolar transmembrane transport
GO_1904613Biological processcellular response to 2,3,7,8-tetrachlorodibenzodioxine
GO_0035434Biological processcopper ion transmembrane transport
GO_0070062Cellular componentextracellular exosome
GO_0005765Cellular componentlysosomal membrane
GO_0015293Molecular functionsymporter activity
GO_0005375Molecular functioncopper ion transmembrane transporter activity
GO_0022857Molecular functiontransmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC46A3
Protein nameLysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (Solute carrier family 46 member 3)
SynonymsFKSG16
DescriptionFUNCTION: Lysosomal proton-coupled steroid conjugate and bile acid transporter. Preferentially recognizes lipophilic steroid conjugates or bile acis as endogenous substrates and seems to mediate escape from lysosomes to the cytoplasm . Modulates hepatic cytosolic copper homeostasis, maybe acting as a lysosomal copper transporter and sequestering copper ions in the lysosome (By similarity). Transports catabolites of non-cleavable antibody-drug conjugates from the lysosome to the cytoplasm . Delivers pathogen-associated molecular patterns to cytosolic pattern recognition receptors as part of the innate immune response to microbes. Selectively transports bacterial muramyl dipeptide (MDP) into the cytosol for recognition by NOD2, triggering inflammatory responses (By similarity). Likely acts as a redundant importer of cyclic GMP-AMP dinucleotides (cGAMPs) in monocyte and macrophage cell lineages . The transport mechanism, its electrogenicity and stoichiometry remain to be elucidated (Probable). .

AccessionsQ7Z3Q1
ENST00000266943.11 [Q7Z3Q1-1]
ENST00000380814.4 [Q7Z3Q1-2]