SLC46A1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SLC46A1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC46A1 at tissue level.

III. Associated gene sets

GO_0055085Biological processtransmembrane transport
GO_0015886Biological processheme transport
GO_0051958Biological processmethotrexate transport
GO_1904447Biological processfolate import across plasma membrane
GO_0046655Biological processfolic acid metabolic process
GO_0098838Biological processfolate transmembrane transport
GO_0098829Biological processintestinal folate absorption
GO_0042168Biological processheme metabolic process
GO_0006879Biological processintracellular iron ion homeostasis
GO_1902600Biological processproton transmembrane transport
GO_0015884Biological processfolic acid transport
GO_0031526Cellular componentbrush border membrane
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0009986Cellular componentcell surface
GO_0005737Cellular componentcytoplasm
GO_0010008Cellular componentendosome membrane
GO_0005768Cellular componentendosome
GO_0016323Cellular componentbasolateral plasma membrane
GO_0015232Molecular functionheme transmembrane transporter activity
GO_0015078Molecular functionproton transmembrane transporter activity
GO_0015293Molecular functionsymporter activity
GO_0015350Molecular functionmethotrexate transmembrane transporter activity
GO_0140211Molecular functionfolic acid:proton symporter activity
GO_0008517Molecular functionfolic acid transmembrane transporter activity
GO_0005542Molecular functionfolic acid binding
GO_0022857Molecular functiontransmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC46A1
Protein nameSolute carrier family 46 member 1
Proton-coupled folate transporter (Solute carrier family 46 member 1)
Proton-coupled folate transporter (HsPCFT) (hPCFT) (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1)
SynonymsPCFT
HCP1
G21
DescriptionFUNCTION: Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force . Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus . Functions at acidic pH via alternate outward- and inward-open conformation states . Protonation of residues in the outward open state primes the protein for transport . Binding of folate promotes breaking of salt bridge network and subsequent closure of the extracellular gate, leading to the inward-open state and release of protons and folate . Also able to transport antifolate drugs, such as methotrexate and pemetrexed, which are established treatments for cancer and autoimmune diseases . Involved in FOLR1-mediated endocytosis by serving as a route of export of folates from acidified endosomes . Also acts as a lower-affinity, pH-independent heme carrier protein and constitutes the main importer of heme in the intestine . Imports heme in the retina and retinal pigment epithelium, in neurons of the hippocampus, in hepatocytes and in the renal epithelial cells . Hence, participates in the trafficking of heme and increases intracellular iron content . .; FUNCTION: [Isoform 2]: Inactive isoform which is not able to mediate proton-coupled folate transport. .

AccessionsQ96NT5
J3KTE6
ENST00000618626.1 [Q96NT5-2]
ENST00000584426.1
ENST00000584995.5
ENST00000612814.5 [Q96NT5-1]
J3QL21
J3QRF7
ENST00000582735.1
ENST00000581516.1
K7EPJ7