SLC35D1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015789Biological processUDP-N-acetylgalactosamine transmembrane transport
GO_0090481Biological processpyrimidine nucleotide-sugar transmembrane transport
GO_0015780Biological processnucleotide-sugar transmembrane transport
GO_1990569Biological processUDP-N-acetylglucosamine transmembrane transport
GO_0015787Biological processUDP-glucuronic acid transmembrane transport
GO_0005794Cellular componentGolgi apparatus
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005462Molecular functionUDP-N-acetylglucosamine transmembrane transporter activity
GO_0015297Molecular functionantiporter activity
GO_0005461Molecular functionUDP-glucuronic acid transmembrane transporter activity
GO_0005463Molecular functionUDP-N-acetylgalactosamine transmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC35D1
Protein nameNucleotide sugar transporter SLC35D1 (Solute carrier family 35 member D1) (UDP-galactose transporter-related protein 7) (UGTrel7) (UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter) (UDP-GlcA/UDP-GalNAc transporter)
SynonymsKIAA0260
UGTREL7
DescriptionFUNCTION: Antiporter that transports nucleotide sugars across the endoplasmic reticulum (ER) membrane in exchange for either their cognate nucleoside monophosphate or another nucleotide sugar . Transports various UDP-sugars including UDP-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc), UDP-N-acetyl-alpha-D-galactosamine (UDP-GalNAc) and UDP-alpha-D-glucuronate (UDP-GlcA), which are used by ER glucosyltransferases as sugar donors for the synthesis of sugar chains of glycoproteins, glycolipids and oligosaccharides . May couple UDP-GlcNAc or UDP-GalNAc efflux to UDP-GlcA influx into the ER lumen that in turn stimulates glucuronidation and subsequent excretion of endobiotics and xenobiotics . Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development (By similarity). .

AccessionsENST00000235345.6 [Q9NTN3-1]
Q9NTN3