I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| amacrine cell | 4 studies | 30% ± 14% | |
| GABAergic neuron | 4 studies | 27% ± 10% | |
| interneuron | 3 studies | 27% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| amacrine cell | 4 studies | 30% ± 14% | |
| GABAergic neuron | 4 studies | 27% ± 10% | |
| interneuron | 3 studies | 27% ± 6% |
Insufficient scRNA-seq data for expression of SLC32A1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 83% | 1677.42 | 2188 / 2642 | 69% | 10.02 | 487 / 705 |
| adrenal gland | 0% | 0.66 | 1 / 258 | 30% | 29.06 | 69 / 230 |
| uterus | 0% | 0 | 0 / 170 | 4% | 0.23 | 17 / 459 |
| eye | 0% | 0 | 0 / 0 | 3% | 0.44 | 2 / 80 |
| ovary | 0% | 0 | 0 / 180 | 2% | 0.12 | 10 / 430 |
| pancreas | 0% | 0 | 0 / 328 | 2% | 0.54 | 4 / 178 |
| peripheral blood | 2% | 5.77 | 20 / 929 | 0% | 0 | 0 / 0 |
| kidney | 1% | 2.11 | 1 / 89 | 0% | 0 | 0 / 901 |
| lung | 0% | 0 | 0 / 578 | 1% | 0.01 | 6 / 1155 |
| intestine | 0% | 0.16 | 1 / 966 | 0% | 0.02 | 2 / 527 |
| bladder | 0% | 0 | 0 / 21 | 0% | 0.01 | 2 / 504 |
| stomach | 0% | 0 | 0 / 359 | 0% | 0.01 | 1 / 286 |
| thymus | 0% | 0.26 | 1 / 653 | 0% | 0.00 | 1 / 605 |
| prostate | 0% | 0 | 0 / 245 | 0% | 0.00 | 1 / 502 |
| breast | 0% | 0 | 0 / 459 | 0% | 0.00 | 2 / 1118 |
| skin | 0% | 0.29 | 2 / 1809 | 0% | 0 | 0 / 472 |
| esophagus | 0% | 0.15 | 1 / 1445 | 0% | 0 | 0 / 183 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| adipose | 0% | 0 | 0 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 0 | 0 / 1335 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 0% | 0 | 0 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0021766 | Biological process | hippocampus development |
| GO_0007269 | Biological process | neurotransmitter secretion |
| GO_0006811 | Biological process | monoatomic ion transport |
| GO_0015816 | Biological process | glycine transport |
| GO_0003333 | Biological process | amino acid transmembrane transport |
| GO_0015812 | Biological process | gamma-aminobutyric acid transport |
| GO_0098700 | Biological process | neurotransmitter loading into synaptic vesicle |
| GO_0051939 | Biological process | gamma-aminobutyric acid import |
| GO_0001762 | Biological process | beta-alanine transport |
| GO_1902600 | Biological process | proton transmembrane transport |
| GO_0098793 | Cellular component | presynapse |
| GO_0061202 | Cellular component | clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0051286 | Cellular component | cell tip |
| GO_0060077 | Cellular component | inhibitory synapse |
| GO_0030672 | Cellular component | synaptic vesicle membrane |
| GO_0043005 | Cellular component | neuron projection |
| GO_0044292 | Cellular component | dendrite terminus |
| GO_0030425 | Cellular component | dendrite |
| GO_0098982 | Cellular component | GABA-ergic synapse |
| GO_0009986 | Cellular component | cell surface |
| GO_0048786 | Cellular component | presynaptic active zone |
| GO_0008021 | Cellular component | synaptic vesicle |
| GO_0044316 | Cellular component | cone cell pedicle |
| GO_0044306 | Cellular component | neuron projection terminus |
| GO_0015171 | Molecular function | amino acid transmembrane transporter activity |
| GO_0015495 | Molecular function | gamma-aminobutyric acid:proton symporter activity |
| GO_0140800 | Molecular function | gamma-aminobutyric acid:proton antiporter activity |
| GO_0015187 | Molecular function | glycine transmembrane transporter activity |
| GO_0140799 | Molecular function | glycine:proton antiporter activity |
| GO_0015185 | Molecular function | gamma-aminobutyric acid transmembrane transporter activity |
| Gene name | SLC32A1 |
| Protein name | Vesicular inhibitory amino acid transporter (GABA and glycine transporter) (Solute carrier family 32 member 1) (Vesicular GABA transporter) (hVIAAT) |
| Synonyms | VIAAT VGAT |
| Description | FUNCTION: Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient (By similarity). May also transport beta-alanine (By similarity). Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake (By similarity). . |
| Accessions | ENST00000217420.2 Q9H598 |
