I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| retina horizontal cell | 5 studies | 34% ± 6% | |
| GABAergic neuron | 3 studies | 26% ± 5% | |
| enteroendocrine cell | 3 studies | 36% ± 13% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| retina horizontal cell | 5 studies | 34% ± 6% | |
| GABAergic neuron | 3 studies | 26% ± 5% | |
| enteroendocrine cell | 3 studies | 36% ± 13% |
Insufficient scRNA-seq data for expression of SLC29A4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 99% | 1929.73 | 2614 / 2642 | 99% | 27.87 | 699 / 705 |
| kidney | 98% | 706.11 | 87 / 89 | 82% | 22.36 | 743 / 901 |
| pancreas | 100% | 1350.65 | 327 / 328 | 61% | 14.83 | 109 / 178 |
| prostate | 77% | 853.01 | 189 / 245 | 73% | 8.47 | 364 / 502 |
| thymus | 98% | 1614.34 | 639 / 653 | 27% | 4.43 | 166 / 605 |
| stomach | 93% | 706.80 | 333 / 359 | 26% | 6.12 | 75 / 286 |
| breast | 81% | 1855.05 | 371 / 459 | 37% | 3.35 | 409 / 1118 |
| liver | 66% | 650.48 | 150 / 226 | 44% | 12.62 | 177 / 406 |
| bladder | 71% | 318.52 | 15 / 21 | 32% | 4.07 | 161 / 504 |
| adrenal gland | 34% | 446.51 | 88 / 258 | 69% | 70.60 | 158 / 230 |
| intestine | 79% | 402.03 | 765 / 966 | 23% | 3.20 | 123 / 527 |
| uterus | 69% | 519.16 | 117 / 170 | 32% | 8.09 | 147 / 459 |
| ovary | 54% | 294.50 | 97 / 180 | 45% | 6.09 | 194 / 430 |
| esophagus | 48% | 237.67 | 694 / 1445 | 48% | 8.55 | 87 / 183 |
| adipose | 94% | 2880.22 | 1129 / 1204 | 0% | 0 | 0 / 0 |
| lung | 21% | 70.74 | 121 / 578 | 62% | 12.01 | 718 / 1155 |
| skin | 47% | 205.29 | 845 / 1809 | 26% | 3.04 | 125 / 472 |
| spleen | 51% | 179.26 | 122 / 241 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 48% | 3.54 | 38 / 80 |
| heart | 47% | 212.40 | 408 / 861 | 0% | 0 | 0 / 0 |
| muscle | 32% | 147.95 | 253 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 18% | 1.40 | 8 / 45 |
| blood vessel | 10% | 103.22 | 127 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 6% | 22.17 | 54 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0015844 | Biological process | monoamine transport |
| GO_0015695 | Biological process | organic cation transport |
| GO_0150104 | Biological process | transport across blood-brain barrier |
| GO_0090494 | Biological process | dopamine uptake |
| GO_1990748 | Biological process | cellular detoxification |
| GO_1901642 | Biological process | nucleoside transmembrane transport |
| GO_0140115 | Biological process | export across plasma membrane |
| GO_0015872 | Biological process | dopamine transport |
| GO_0042908 | Biological process | xenobiotic transport |
| GO_0051620 | Biological process | norepinephrine uptake |
| GO_0001692 | Biological process | histamine metabolic process |
| GO_0006837 | Biological process | serotonin transport |
| GO_0098655 | Biological process | monoatomic cation transmembrane transport |
| GO_0006836 | Biological process | neurotransmitter transport |
| GO_0032238 | Biological process | adenosine transport |
| GO_0015874 | Biological process | norepinephrine transport |
| GO_0051610 | Biological process | serotonin uptake |
| GO_0051608 | Biological process | histamine transport |
| GO_0051625 | Biological process | epinephrine uptake |
| GO_0051615 | Biological process | histamine uptake |
| GO_1903825 | Biological process | organic acid transmembrane transport |
| GO_0048241 | Biological process | epinephrine transport |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0098793 | Cellular component | presynapse |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016323 | Cellular component | basolateral plasma membrane |
| GO_0005342 | Molecular function | organic acid transmembrane transporter activity |
| GO_0015562 | Molecular function | efflux transmembrane transporter activity |
| GO_0015101 | Molecular function | organic cation transmembrane transporter activity |
| GO_0005326 | Molecular function | neurotransmitter transmembrane transporter activity |
| GO_0008504 | Molecular function | monoamine transmembrane transporter activity |
| GO_0019534 | Molecular function | toxin transmembrane transporter activity |
| GO_0042910 | Molecular function | xenobiotic transmembrane transporter activity |
| GO_0008324 | Molecular function | monoatomic cation transmembrane transporter activity |
| GO_0005337 | Molecular function | nucleoside transmembrane transporter activity |
| Gene name | SLC29A4 |
| Protein name | Solute carrier family 29 member 4 Equilibrative nucleoside transporter 4 (hENT4) (Plasma membrane monoamine transporter) (PMAT) (Solute carrier family 29 member 4) |
| Synonyms | PMAT PSEC0113 ENT4 |
| Description | FUNCTION: Electrogenic voltage-dependent transporter that mediates the transport of a variety of endogenous bioactive amines, cationic xenobiotics and drugs . Utilizes the physiologic inside-negative membrane potential as a driving force to facilitate cellular uptake of organic cations . Functions as a Na(+)- and Cl(-)-independent bidirectional transporter . Substrate transport is pH-dependent and enhanced under acidic condition, which is most likely the result of allosteric changes in the transporter structure . Implicated in monoamine neurotransmitters uptake such as serotonin, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the central nervous system . Also responsible for the uptake of bioactive amines and drugs through the blood-cerebrospinal fluid (CSF) barrier, from the CSF into choroid plexus epithelial cells, thereby playing a significant role in the clearance of cationic neurotoxins, xenobiotics and metabolic waste in the brain (By similarity). Involved in bidirectional transport of the purine nucleoside adenosine and plays a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia . May be involved in organic cation uptake from the tubular lumen into renal tubular cells, thereby contributing to organic cation reabsorption in the kidney . Also transports guanidine . . |
| Accessions | Q7RTT9 ENST00000396872.8 [Q7RTT9-1] ENST00000406453.3 [Q7RTT9-2] C9IYM7 ENST00000444741.5 C9JZA2 ENST00000297195.8 [Q7RTT9-1] ENST00000434816.5 |
