SLC25A47 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC25A47 at tissue level.

III. Associated gene sets

GO_0006810Biological processtransport
GO_0015876Biological processacetyl-CoA transport
GO_0035352Biological processNAD transmembrane transport
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0022857Molecular functiontransmembrane transporter activity
GO_0051724Molecular functionNAD transmembrane transporter activity
GO_0008521Molecular functionacetyl-CoA transmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC25A47
Protein nameSolute carrier family 25 member 47 (Hepatocellular carcinoma down-regulated mitochondrial carrier protein) (Mitochondrial NAD(+) transporter SLC25A47)
Solute carrier family 25 member 47
SynonymsHDMCP
HMFN1655
C14orf68
DescriptionFUNCTION: Mitochondrial NAD(+) transporter that acts as a 'metabolic gate' in hepatic lipogenesis. Provides NAD(+) substrate to mitochondrial SIRT3 deacetylase and enables its NAD(+)-dependent activities in mitochondrial energy metabolism. This triggers downstream activation of PRKAA1/AMPK-alpha signaling cascade that negatively regulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. May transport other mitochondrial metabolites having an aromatic nucleotide and phosphate groups, such as acetyl-CoA. Does not transport amino acids. The transport mechanism remains to be elucidated. .

AccessionsENST00000557052.1
G3V374
Q6Q0C1
ENST00000361529.5 [Q6Q0C1-1]