SLC25A15 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SLC25A15 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC25A15 at tissue level.

III. Associated gene sets

GO_1903826Biological processL-arginine transmembrane transport
GO_0000050Biological processurea cycle
GO_1990575Biological processmitochondrial L-ornithine transmembrane transport
GO_1903401Biological processL-lysine transmembrane transport
GO_0016020Cellular componentmembrane
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0061459Molecular functionL-arginine transmembrane transporter activity
GO_0015189Molecular functionL-lysine transmembrane transporter activity
GO_0000064Molecular functionL-ornithine transmembrane transporter activity
GO_0015297Molecular functionantiporter activity

IV. Literature review

[source]
Gene nameSLC25A15
Protein nameSolute carrier family 25 member 15
Mitochondrial ornithine transporter 1 (Solute carrier family 25 member 15)
SynonymsORNT1
ORC1
SP1855
DescriptionFUNCTION: Mitochondrial ornithine-citrulline antiporter (Probable). Catalyzes the exchange between cytosolic ornithine and mitochondrial citrulline plus an H(+), the proton compensates the positive charge of ornithine thus leading to an electroneutral transport. Plays a crucial role in the urea cycle, by connecting the cytosolic and the intramitochondrial reactions of the urea cycle (Probable). Lysine and arginine are also transported by the antiport mechanism (Probable). In addition, catalyzes an electroneutral exchange of ornithine or lysine for H(+), a reaction driven by the pH gradient across the inner membrane (By similarity). .

AccessionsF2Z354
ENST00000470509.1
Q5VZD9
ENST00000417731.5
ENST00000338625.9
Q9Y619
ENST00000707033.1