SLC25A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046949Biological processfatty-acyl-CoA biosynthetic process
GO_0006094Biological processgluconeogenesis
GO_0006843Biological processmitochondrial citrate transmembrane transport
GO_0070062Cellular componentextracellular exosome
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0015137Molecular functioncitrate transmembrane transporter activity
GO_0015297Molecular functionantiporter activity
GO_0015142Molecular functiontricarboxylic acid transmembrane transporter activity
GO_0071913Molecular functioncitrate secondary active transmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC25A1
Protein nameTricarboxylate transport protein, mitochondrial (Citrate transport protein) (CTP) (Mitochondrial citrate carrier) (CIC) (Solute carrier family 25 member 1) (Tricarboxylate carrier protein)
Citrate transport protein
SynonymshCG_17246
SLC20A3
DescriptionFUNCTION: Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate . Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extend cis-aconitate, maleate and succinate . In the cytoplasm citrate is important in the regulation of glycolysis through a feedback mechanism and in the production of acetyl-CoA which is needed for the synthesis of fatty acids, sterols, prostaglandins, dolichol and coenzyme Q (CoQ). Required for proper neuromuscular junction formation (Probable). .

AccessionsD9HTE9
ENST00000215882.10
P53007
D3DX16
ENST00000451283.5