SLC18B1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051610Biological processserotonin uptake
GO_0000296Biological processspermine transport
GO_0015848Biological processspermidine transport
GO_1902047Biological processpolyamine transmembrane transport
GO_1902600Biological processproton transmembrane transport
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0030667Cellular componentsecretory granule membrane
GO_0015311Molecular functionmonoamine:proton antiporter activity
GO_0022857Molecular functiontransmembrane transporter activity
GO_0015312Molecular functionpolyamine:proton antiporter activity

IV. Literature review

[source]
Gene nameSLC18B1
Protein nameSolute carrier family 18 member B1
MFS-type transporter SLC18B1 (Solute carrier family 18 member B1) (Vesicular polyamine transporter) (VPAT)
SynonymsC6orf192
DescriptionFUNCTION: Proton-coupled polyamine antiporter involved in the translocation of polyamines from cytosol into secretory vesicles prior to their release via exocytosis. Uses the electrochemical proton gradient generated by a V-type proton-pumping ATPase to couple the efflux of protons with the uptake of a polyamine molecule . Facilitates vesicular storage of spermine and spermidine in astrocytes with an impact on glutamatergic neuronal transmission and memory formation (By similarity). Upon antigen stimulation, regulates polyamine accumulation and release in mast cell secretory granules, which in turn potentiates mast cell degranulation and histamine secretion (By similarity). .

AccessionsQ6NT16
A0A3B3ISL3
ENST00000647932.1
ENST00000650298.1
ENST00000650136.1
A0A3B3ITL9
ENST00000275227.9
A0A3B3IT67
A0A3B3IU67
ENST00000650278.1