SLC18A1 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC18A1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	69%	494.69	178 / 258	66%	230.03	151 / 230
intestine	75%	53.88	723 / 966	35%	2.90	183 / 527
stomach	80%	45.33	287 / 359	21%	1.08	60 / 286
prostate	84%	24.20	206 / 245	14%	0.34	71 / 502
spleen	91%	32.29	220 / 241	0%	0	0 / 0
brain	50%	11.84	1333 / 2642	16%	0.52	111 / 705
lung	39%	3.29	226 / 578	2%	0.11	28 / 1155
peripheral blood	36%	3.50	334 / 929	0%	0	0 / 0
heart	34%	3.34	292 / 861	0%	0	0 / 0
bladder	19%	1.90	4 / 21	10%	0.71	51 / 504
skin	17%	2.10	299 / 1809	11%	0.87	52 / 472
thymus	24%	3.73	155 / 653	0%	0.01	2 / 605
breast	20%	1.32	90 / 459	2%	0.28	25 / 1118
kidney	20%	1.73	18 / 89	0%	0.00	2 / 901
adipose	20%	1.18	235 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	17%	0.28	5 / 29
esophagus	9%	0.81	125 / 1445	7%	0.74	13 / 183
pancreas	7%	0.36	23 / 328	4%	0.88	8 / 178
blood vessel	11%	0.69	143 / 1335	0%	0	0 / 0
uterus	9%	0.42	15 / 170	1%	0.02	6 / 459
liver	5%	0.27	11 / 226	1%	0.19	3 / 406
ovary	4%	0.19	8 / 180	0%	0.00	1 / 430
muscle	3%	0.22	28 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	2%	0.06	1 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0051610	Biological process	serotonin uptake
GO_1902600	Biological process	proton transmembrane transport
GO_0015842	Biological process	aminergic neurotransmitter loading into synaptic vesicle
GO_0042908	Biological process	xenobiotic transport
GO_0015844	Biological process	monoamine transport
GO_0043195	Cellular component	terminal bouton
GO_0030672	Cellular component	synaptic vesicle membrane
GO_0070083	Cellular component	clathrin-sculpted monoamine transport vesicle membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0042910	Molecular function	xenobiotic transmembrane transporter activity
GO_0005335	Molecular function	serotonin:sodium:chloride symporter activity
GO_0015311	Molecular function	monoamine:proton antiporter activity
GO_0008504	Molecular function	monoamine transmembrane transporter activity

Gene name	SLC18A1
Protein name	Solute carrier family 18 member A1 Chromaffin granule amine transporter (Solute carrier family 18 member 1) (Vesicular amine transporter 1) (VAT1) SLC18A1 protein (Solute carrier family 18 member A1)
Synonyms	VMAT1 VAT1
Description	FUNCTION: [Isoform 1]: Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports catecholamines and indolamines with higher affinity for serotonin . Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates presynaptic monoaminergic vesicle transport in the amygdala and prefrontal brain regions related with emotion processing in response to environmental stimuli . .; FUNCTION: [Isoform 2]: Unable to uptake serotonin. .
Accessions	P54219 ENST00000381608.8 [P54219-2] ENST00000522513.5 E5RK12 Q96GL6 ENST00000276373.10 [P54219-1] ENST00000440926.3 [P54219-1] ENST00000519026.5 [P54219-3] ENST00000437980.3 [P54219-2] ENST00000517776.5 ENST00000265808.11 [P54219-3]

SLC18A1 report