SLC17A6 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC17A6 at tissue level.

III. Associated gene sets

GO_0055062Biological processphosphate ion homeostasis
GO_0015813Biological processL-glutamate transmembrane transport
GO_0006811Biological processmonoatomic ion transport
GO_0071805Biological processpotassium ion transmembrane transport
GO_0044341Biological processsodium-dependent phosphate transport
GO_0006820Biological processmonoatomic anion transport
GO_1902476Biological processchloride transmembrane transport
GO_0051938Biological processL-glutamate import
GO_0006817Biological processphosphate ion transport
GO_0098700Biological processneurotransmitter loading into synaptic vesicle
GO_1990384Biological processhyaloid vascular plexus regression
GO_0050803Biological processregulation of synapse structure or activity
GO_0035725Biological processsodium ion transmembrane transport
GO_1902600Biological processproton transmembrane transport
GO_0035249Biological processsynaptic transmission, glutamatergic
GO_0005886Cellular componentplasma membrane
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0043005Cellular componentneuron projection
GO_0034707Cellular componentchloride channel complex
GO_0060076Cellular componentexcitatory synapse
GO_0005436Molecular functionsodium:phosphate symporter activity
GO_0005326Molecular functionneurotransmitter transmembrane transporter activity
GO_0015386Molecular functionpotassium:proton antiporter activity
GO_0140788Molecular functionL-glutamate uniporter activity
GO_0005313Molecular functionL-glutamate transmembrane transporter activity
GO_0005254Molecular functionchloride channel activity

IV. Literature review

[source]
Gene nameSLC17A6
Protein nameVesicular glutamate transporter 2 (VGluT2) (Differentiation-associated BNPI) (Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 6)
Alternative protein SLC17A6
SynonymsVGLUT2
DNPI
DescriptionFUNCTION: Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate . At the synaptic vesicle membrane, mainly functions as a uniporter which transports preferentially L-glutamate but also, phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells . The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane . In addition, functions as a chloride channel that allows the chloride permeation through the synaptic vesicle membrane therefore affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity). Moreover, functions as a vesicular K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake (By similarity). The vesicular H(+)/H(+) antiport activity is electroneutral (By similarity). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (Probable) . The symporter activity is driven by an inside negative membrane potential and is electrogenic (Probable). Also involved in the regulation of retinal hyaloid vessel regression during postnatal development (By similarity). May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas (By similarity). .

AccessionsQ9P2U8
ENST00000263160.4
L0R6P3
L8ECI6