SLC16A2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015718Biological processmonocarboxylic acid transport
GO_0089718Biological processamino acid import across plasma membrane
GO_0006590Biological processthyroid hormone generation
GO_0070460Biological processthyroid-stimulating hormone secretion
GO_0042403Biological processthyroid hormone metabolic process
GO_0006520Biological processamino acid metabolic process
GO_2000178Biological processnegative regulation of neural precursor cell proliferation
GO_0070327Biological processthyroid hormone transport
GO_0150104Biological processtransport across blood-brain barrier
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0015171Molecular functionamino acid transmembrane transporter activity
GO_0015349Molecular functionthyroid hormone transmembrane transporter activity
GO_0008028Molecular functionmonocarboxylic acid transmembrane transporter activity
GO_0042802Molecular functionidentical protein binding

IV. Literature review

[source]
Gene nameSLC16A2
Protein nameSolute carrier family 16 member 2
Monocarboxylate transporter 8 (MCT 8) (Monocarboxylate transporter 7) (MCT 7) (Solute carrier family 16 member 2) (X-linked PEST-containing transporter)
SynonymsMCT7
XPCT
MCT8
DescriptionFUNCTION: Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormones across the cell membrane independently of pH or a Na(+) gradient. Major substrates are the iodothyronines T3 and T4 and to a lesser extent rT3 and 3,3-diiodothyronine (3,3'-T2) . Acts as an important mediator of thyroid hormone transport, especially T3, through the blood-brain barrier (Probable) . .

AccessionsA0A1B0GVB4
ENST00000590447.1
ENST00000587091.6
ENST00000636771.1
P36021
K7ELT4