SIRT5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010566Biological processregulation of ketone biosynthetic process
GO_0036046Biological processprotein demalonylation
GO_0006476Biological processprotein deacetylation
GO_2000378Biological processnegative regulation of reactive oxygen species metabolic process
GO_0061698Biological processprotein deglutarylation
GO_0036048Biological processprotein desuccinylation
GO_0031667Biological processresponse to nutrient levels
GO_0007005Biological processmitochondrion organization
GO_0036049Biological processpeptidyl-lysine desuccinylation
GO_0010667Biological processnegative regulation of cardiac muscle cell apoptotic process
GO_0036047Biological processpeptidyl-lysine demalonylation
GO_0040029Biological processepigenetic regulation of gene expression
GO_0005739Cellular componentmitochondrion
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005634Cellular componentnucleus
GO_0003950Molecular functionNAD+ ADP-ribosyltransferase activity
GO_0036055Molecular functionprotein-succinyllysine desuccinylase activity
GO_0061697Molecular functionprotein-glutaryllysine deglutarylase activity
GO_0036054Molecular functionprotein-malonyllysine demalonylase activity
GO_0070403Molecular functionNAD+ binding
GO_0034979Molecular functionNAD-dependent protein lysine deacetylase activity
GO_0008270Molecular functionzinc ion binding
GO_1990404Molecular functionNAD+-protein ADP-ribosyltransferase activity

IV. Literature review

[source]
Gene nameSIRT5
Protein nameSirtuin (Silent mating type information regulation 2 homolog) 5 (S. cerevisiae), isoform CRA_c (Sirtuin 5)
Sirtuin 5
NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 2.3.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5)
SynonymsSIR2L5
DKFZp686L2375
hCG_37419
DescriptionFUNCTION: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins . Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting . Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species . Activates SHMT2 by mediating its desuccinylation . Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. .

FUNCTION: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox. .

FUNCTION: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox. .

AccessionsA0A7P0T877
ENST00000680151.1 [Q9NXA8-1]
ENST00000680442.1
ENST00000681818.1
A0A7P0Z4F6
ENST00000680402.1
ENST00000680852.1
ENST00000681012.1
ENST00000679658.1
ENST00000606427.5
ENST00000681243.1
ENST00000606117.2 [Q9NXA8-1]
ENST00000681231.1
Q7Z3A0
Q9NXA8
ENST00000680754.1
U3KQT8
ENST00000397350.7 [Q9NXA8-1]
ENST00000680432.1 [Q9NXA8-1]
A0A7P0T915
A0A7P0T9X1
A0A7P0Z490
ENST00000359782.8 [Q9NXA8-3]
A0A7P0Z4N6
A0A7P0TA05
ENST00000679922.1
ENST00000679663.1
ENST00000681905.1
ENST00000379262.8 [Q9NXA8-2]
ENST00000680937.1
A0A7P0T9N1
A0A7P0TBF5
ENST00000680707.1 [Q9NXA8-2]
ENST00000379250.10