SIGLEC11 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SIGLEC11 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SIGLEC11 at tissue level.

III. Associated gene sets

GO_0007155Biological processcell adhesion
GO_0005886Cellular componentplasma membrane
GO_0019902Molecular functionphosphatase binding
GO_0030246Molecular functioncarbohydrate binding
GO_0033691Molecular functionsialic acid binding

IV. Literature review

[source]
Gene nameSIGLEC11
Protein nameSialic acid binding Ig like lectin 11
Sialic acid-binding Ig-like lectin 11 (Sialic acid-binding lectin 11) (Siglec-11)
SynonymsUNQ9222/PRO28718
DescriptionFUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

AccessionsQ96RL6
ENST00000447370.6 [Q96RL6-1]
ENST00000426296.1
H7C2S0
ENST00000426971.2 [Q96RL6-2]