I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| basal cell | 8 studies | 29% ± 8% | |
| club cell | 4 studies | 27% ± 9% | |
| secretory cell | 4 studies | 36% ± 17% | |
| respiratory goblet cell | 3 studies | 23% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| basal cell | 8 studies | 29% ± 8% | |
| club cell | 4 studies | 27% ± 9% | |
| secretory cell | 4 studies | 36% ± 17% | |
| respiratory goblet cell | 3 studies | 23% ± 3% |
Insufficient scRNA-seq data for expression of SERPINB4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 40% | 2273.85 | 575 / 1445 | 52% | 59.34 | 95 / 183 |
| tonsil | 0% | 0 | 0 / 0 | 67% | 115.84 | 30 / 45 |
| uterus | 2% | 199.69 | 4 / 170 | 61% | 277.32 | 282 / 459 |
| lung | 7% | 45.75 | 42 / 578 | 29% | 30.12 | 339 / 1155 |
| skin | 22% | 237.88 | 396 / 1809 | 9% | 9.93 | 41 / 472 |
| prostate | 24% | 167.31 | 59 / 245 | 3% | 0.64 | 17 / 502 |
| bladder | 0% | 0 | 0 / 21 | 26% | 30.69 | 133 / 504 |
| pancreas | 0% | 0 | 0 / 328 | 17% | 5.47 | 30 / 178 |
| intestine | 1% | 0.82 | 7 / 966 | 4% | 3.07 | 22 / 527 |
| stomach | 1% | 2.78 | 5 / 359 | 2% | 2.16 | 7 / 286 |
| breast | 2% | 2.20 | 8 / 459 | 2% | 2.65 | 23 / 1118 |
| kidney | 2% | 2.70 | 2 / 89 | 1% | 0.29 | 5 / 901 |
| ovary | 1% | 0.31 | 1 / 180 | 2% | 0.42 | 7 / 430 |
| liver | 1% | 2.48 | 3 / 226 | 1% | 0.85 | 3 / 406 |
| adipose | 1% | 3.14 | 14 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 1% | 1.94 | 7 / 803 | 0% | 0 | 0 / 0 |
| adrenal gland | 0% | 0 | 0 / 258 | 1% | 0.71 | 2 / 230 |
| thymus | 1% | 1.08 | 4 / 653 | 0% | 0.02 | 1 / 605 |
| peripheral blood | 1% | 22.34 | 5 / 929 | 0% | 0 | 0 / 0 |
| heart | 0% | 0.41 | 4 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 1.51 | 4 / 1335 | 0% | 0 | 0 / 0 |
| brain | 0% | 0.11 | 3 / 2642 | 0% | 0.04 | 1 / 705 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0042270 | Biological process | protection from natural killer cell mediated cytotoxicity |
| GO_0030162 | Biological process | regulation of proteolysis |
| GO_0010466 | Biological process | negative regulation of peptidase activity |
| GO_0010951 | Biological process | negative regulation of endopeptidase activity |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005829 | Cellular component | cytosol |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0002020 | Molecular function | protease binding |
| GO_0019899 | Molecular function | enzyme binding |
| GO_0004867 | Molecular function | serine-type endopeptidase inhibitor activity |
| Gene name | SERPINB4 |
| Protein name | SCCA2b (Serpin peptidase inhibitor, clade B (Ovalbumin), member 4, isoform CRA_a) Serpin family B member 4 Squamous cell carcinoma antigen 2 Serpin B4 (Leupin) (Peptidase inhibitor 11) (PI-11) (Squamous cell carcinoma antigen 2) (SCCA-2) |
| Synonyms | SCCA2 PI11 hCG_1775797 |
| Description | FUNCTION: May act as a protease inhibitor to modulate the host immune response against tumor cells. |
| Accessions | Q9BYF7 C9JZ65 ENST00000436264.1 Q86W05 H0Y5H9 Q86W03 ENST00000341074.10 ENST00000413673.5 P48594 |
