SERPINA4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SERPINA4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SERPINA4 at tissue level.

III. Associated gene sets

GO_0010951Biological processnegative regulation of endopeptidase activity
GO_0005615Cellular componentextracellular space
GO_0070062Cellular componentextracellular exosome
GO_0031089Cellular componentplatelet dense granule lumen
GO_0005576Cellular componentextracellular region
GO_0004867Molecular functionserine-type endopeptidase inhibitor activity

IV. Literature review

[source]
Gene nameSERPINA4
Protein nameKallistatin (Kallikrein inhibitor) (Peptidase inhibitor 4) (PI-4) (Serpin A4)
Serpin peptidase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 4, isoform CRA_a (Testicular secretory protein Li 22)
SynonymsPI4
hCG_22333
KST
DescriptionFUNCTION: Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein. .

AccessionsP29622
ENST00000298841.5
ENST00000555095.5
A0A024R6I9
ENST00000557004.6