SELENOI report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006646Biological processphosphatidylethanolamine biosynthetic process
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005794Cellular componentGolgi apparatus
GO_0004307Molecular functionethanolaminephosphotransferase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameSELENOI
Protein nameEthanolaminephosphotransferase 1
Ethanolaminephosphotransferase 1 (hEPT1) (EC 2.7.8.1) (Selenoprotein I) (SelI)
Selenoprotein I
SynonymsSELI
EPT1
KIAA1724
DescriptionFUNCTION: Ethanolaminephosphotransferase that catalyzes the transfer of phosphoethanolamine/PE from CDP-ethanolamine to lipid acceptors, the final step in the synthesis of PE via the 'Kennedy' pathway . PE is the second most abundant phospholipid of membranes in mammals and is involved in various membrane-related cellular processes . The enzyme is critical for the synthesis of several PE species and could also catalyze the synthesis of ether-linked phospholipids like plasmanyl- and plasmenyl-PE which could explain it is required for proper myelination and neurodevelopment . .

AccessionsENST00000442141.5
ENST00000260585.12
C9JAG1
ENST00000447170.1
C9JEZ2
G1UI38
Q9C0D9