SCN7A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0055078Biological processsodium ion homeostasis
GO_0086002Biological processcardiac muscle cell action potential involved in contraction
GO_0007231Biological processosmosensory signaling pathway
GO_0035725Biological processsodium ion transmembrane transport
GO_0019725Biological processcellular homeostasis
GO_0009617Biological processresponse to bacterium
GO_0001518Cellular componentvoltage-gated sodium channel complex
GO_0097386Cellular componentglial cell projection
GO_0005886Cellular componentplasma membrane
GO_1990760Molecular functionosmolarity-sensing monoatomic cation channel activity
GO_0005272Molecular functionsodium channel activity
GO_0005248Molecular functionvoltage-gated sodium channel activity
GO_0044325Molecular functiontransmembrane transporter binding

IV. Literature review

[source]
Gene nameSCN7A
Protein nameSodium voltage-gated channel alpha subunit 7
Sodium channel protein type 7 subunit alpha (Atypical sodium channel Nav2.1) (Nax channel) (Sodium channel protein type VII subunit alpha)
SynonymsSCN6A
DescriptionFUNCTION: Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient . In glial cells of the central nervous system, senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake through activation of nearby neurons to maintain appropriate sodium levels in the body (By similarity). By mediating sodium influx into keratinocytes, also plays a role in skin barrier homeostasis . .

AccessionsF8WD82
ENST00000424326.5
Q01118
ENST00000643258.1
ENST00000650747.1
ENST00000419992.6
A0A494C195
ENST00000441411.2
C9JW43