Name | Number of supported studies | Average coverage | |
---|---|---|---|
retinal pigment epithelial cell | 4 studies | 81% ± 18% |
Insufficient scRNA-seq data for expression of RPE65 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 82% | 87.76 | 2169 / 2642 | 94% | 20.36 | 661 / 705 |
prostate | 86% | 79.58 | 211 / 245 | 31% | 0.80 | 155 / 502 |
uterus | 51% | 26.60 | 86 / 170 | 9% | 1.62 | 41 / 459 |
esophagus | 22% | 3.69 | 314 / 1445 | 23% | 1.73 | 42 / 183 |
bladder | 33% | 5.00 | 7 / 21 | 7% | 0.42 | 36 / 504 |
intestine | 33% | 4.71 | 314 / 966 | 5% | 0.23 | 25 / 527 |
breast | 35% | 16.51 | 160 / 459 | 2% | 0.05 | 22 / 1118 |
skin | 19% | 3.18 | 342 / 1809 | 15% | 0.62 | 69 / 472 |
stomach | 24% | 2.91 | 86 / 359 | 4% | 0.41 | 12 / 286 |
blood vessel | 20% | 3.61 | 267 / 1335 | 0% | 0 | 0 / 0 |
ovary | 18% | 3.61 | 32 / 180 | 1% | 0.02 | 4 / 430 |
adipose | 17% | 4.25 | 204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 14% | 1.34 | 11 / 80 |
spleen | 14% | 1.48 | 33 / 241 | 0% | 0 | 0 / 0 |
heart | 11% | 1.37 | 92 / 861 | 0% | 0 | 0 / 0 |
lung | 4% | 0.47 | 23 / 578 | 5% | 0.24 | 63 / 1155 |
tonsil | 0% | 0 | 0 / 0 | 9% | 0.37 | 4 / 45 |
pancreas | 1% | 0.05 | 2 / 328 | 4% | 0.31 | 8 / 178 |
peripheral blood | 5% | 0.51 | 46 / 929 | 0% | 0 | 0 / 0 |
kidney | 3% | 0.25 | 3 / 89 | 0% | 0.00 | 2 / 901 |
adrenal gland | 1% | 0.09 | 3 / 258 | 1% | 0.01 | 2 / 230 |
thymus | 2% | 0.14 | 12 / 653 | 0% | 0 | 0 / 605 |
muscle | 0% | 0.02 | 3 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
liver | 0% | 0 | 0 / 226 | 0% | 0 | 0 / 406 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0007601 | Biological process | visual perception |
GO_0001895 | Biological process | retina homeostasis |
GO_1901827 | Biological process | zeaxanthin biosynthetic process |
GO_0007623 | Biological process | circadian rhythm |
GO_0001523 | Biological process | retinoid metabolic process |
GO_0050908 | Biological process | detection of light stimulus involved in visual perception |
GO_0006776 | Biological process | vitamin A metabolic process |
GO_0042574 | Biological process | retinal metabolic process |
GO_0042572 | Biological process | retinol metabolic process |
GO_0003407 | Biological process | neural retina development |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0044297 | Cellular component | cell body |
GO_0005634 | Cellular component | nucleus |
GO_0003834 | Molecular function | beta-carotene 15,15'-dioxygenase activity |
GO_0052885 | Molecular function | all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity |
GO_0001786 | Molecular function | phosphatidylserine binding |
GO_0031210 | Molecular function | phosphatidylcholine binding |
GO_0050251 | Molecular function | retinol isomerase activity |
GO_0052884 | Molecular function | all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0016853 | Molecular function | isomerase activity |
GO_1901612 | Molecular function | cardiolipin binding |
Gene name | RPE65 |
Protein name | Retinoid isomerohydrolase (EC 3.1.1.64) (All-trans-retinyl-palmitate hydrolase) (Lutein isomerase) (Meso-zeaxanthin isomerase) (EC 5.3.3.22) (Retinal pigment epithelium-specific 65 kDa protein) (Retinol isomerase) Retinal pigment epithelium-specific protein 65 kDa Mutant retinal pigment epithelium 65KDa protein Alternative protein RPE65 Retinal pigment epithelium-specific protein |
Synonyms | |
Description | FUNCTION: Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore . Essential for the production of 11-cis retinal for both rod and cone photoreceptors . Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid . The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (By similarity). . |
Accessions | H9ND74 Q2EKB8 L8EC55 ENST00000262340.6 Q16518 C7FEP0 |