RNF212 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of RNF212 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RNF212 at tissue level.

III. Associated gene sets

GO_0007131Biological processreciprocal meiotic recombination
GO_0051026Biological processchiasma assembly
GO_0016925Biological processprotein sumoylation
GO_0006311Biological processmeiotic gene conversion
GO_0007129Biological processhomologous chromosome pairing at meiosis
GO_0000795Cellular componentsynaptonemal complex
GO_0019789Molecular functionSUMO transferase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameRNF212
Protein nameRing finger protein 212
Probable E3 SUMO-protein ligase RNF212 (EC 2.3.2.-) (Probable E3 SUMO-protein transferase RNF212) (RING finger protein 212)
Synonyms
DescriptionFUNCTION: SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity). .

AccessionsQ495C1
ENST00000508428.5
D6R9L2
ENST00000333673.5 [Q495C1-6]
ENST00000506730.5
ENST00000433731.7 [Q495C1-1]
ENST00000511620.5 [Q495C1-2]
D6RA97
A0A8V8TN20
ENST00000698262.1
ENST00000510715.5
ENST00000382968.9 [Q495C1-5]