RNF123 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of RNF123 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RNF123 at tissue level.

III. Associated gene sets

GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0051603Biological processproteolysis involved in protein catabolic process
GO_0051604Biological processprotein maturation
GO_0000209Biological processprotein polyubiquitination
GO_0005829Cellular componentcytosol
GO_0031965Cellular componentnuclear membrane
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameRNF123
Protein nameRING-type E3 ubiquitin transferase (EC 2.3.2.27)
E3 ubiquitin-protein ligase RNF123 (EC 2.3.2.27) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123)
Ring finger protein 123
SynonymsKPC1
FP1477
DescriptionFUNCTION: Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase . Promotes the ubiquitination and proteasome-mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle . Also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B: acts by catalyzing ubiquitination of the NFKB1 p105 precursor, leading to limited proteasomal degradation of NFKB1 p105 and generation of the active NFKB1 p50 subunit . Functions also as an inhibitor of innate antiviral signaling mediated by RIGI and IFIH1 independently of its E3 ligase activity . Interacts with the N-terminal CARD domains of RIGI and IFIH1 and competes with the downstream adapter MAVS . .

AccessionsC9JI97
ENST00000433785.1
ENST00000327697.11 [Q5XPI4-1]
ENST00000444689.1
ENST00000629802.1
ENST00000454491.5
H7C3U1
C9JS59
F8WB91
ENST00000457726.5
ENST00000432042.5
ENST00000443204.3
C9JN91
Q5XPI4
C9J266