RLIG1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002244Biological processhematopoietic progenitor cell differentiation
GO_0018117Biological processprotein adenylylation
GO_0042245Biological processRNA repair
GO_0000302Biological processresponse to reactive oxygen species
GO_0003972Molecular functionRNA ligase (ATP) activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameRLIG1
Protein nameRNA ligase 1 (EC 6.5.1.3) (RNA ligase) (Rnl)
Chromosome 12 open reading frame 29
SynonymsC12orf29
hCG_27306
DescriptionFUNCTION: Functions as an RNA ligase, in vitro . The ligation reaction entails three nucleotidyl transfer steps . In the first step, the RNA ligase reacts with ATP in the absence of nucleic acid to form a covalent ligase-AMP intermediate and release pyrophosphate . In step 2, the ligase-AMP binds to the nucleic acid and transfers the adenylate to the 5'-PO4 terminus to form an adenylylated intermediate . In step 3, the RNA ligase directs the attack of the 3'-OH on the 5'-phosphoanhydride linkage, resulting in a repaired 3'-5' phosphodiester and release of AMP . Exhibits selectivity for single-stranded RNA substrates and may not have nick-sealing activity on double-stranded DNA-RNA hybrids . May play a role in maintaining RNA integrity under stress conditions, for example in response to reactive oxygen species (ROS) . .

AccessionsENST00000552121.5 [Q8N999-2]
Q8N999
ENST00000356891.4 [Q8N999-1]
ENST00000453037.7 [Q8N999-2]
ENST00000552847.5
G3V1X7
ENST00000550333.5 [Q8N999-2]