I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| hepatocyte | 4 studies | 30% ± 8% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| hepatocyte | 4 studies | 30% ± 8% |
Insufficient scRNA-seq data for expression of RDH16 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 32009.35 | 226 / 226 | 92% | 111.69 | 375 / 406 |
| prostate | 100% | 690.42 | 244 / 245 | 87% | 7.18 | 435 / 502 |
| uterus | 99% | 150.29 | 168 / 170 | 57% | 4.46 | 262 / 459 |
| breast | 93% | 77.23 | 429 / 459 | 57% | 3.33 | 636 / 1118 |
| esophagus | 94% | 100.70 | 1353 / 1445 | 54% | 2.08 | 99 / 183 |
| bladder | 100% | 72.86 | 21 / 21 | 44% | 1.95 | 220 / 504 |
| lung | 98% | 97.79 | 564 / 578 | 39% | 1.50 | 455 / 1155 |
| brain | 90% | 77.74 | 2365 / 2642 | 47% | 0.88 | 334 / 705 |
| pancreas | 93% | 62.44 | 306 / 328 | 25% | 0.71 | 44 / 178 |
| intestine | 93% | 79.11 | 903 / 966 | 19% | 0.81 | 100 / 527 |
| stomach | 90% | 57.47 | 323 / 359 | 21% | 0.42 | 60 / 286 |
| ovary | 98% | 115.83 | 177 / 180 | 7% | 0.12 | 32 / 430 |
| kidney | 99% | 84.90 | 88 / 89 | 4% | 0.18 | 35 / 901 |
| thymus | 93% | 71.43 | 608 / 653 | 7% | 0.11 | 45 / 605 |
| spleen | 100% | 459.38 | 241 / 241 | 0% | 0 | 0 / 0 |
| adrenal gland | 83% | 51.14 | 215 / 258 | 8% | 0.18 | 18 / 230 |
| adipose | 88% | 63.96 | 1059 / 1204 | 0% | 0 | 0 / 0 |
| skin | 77% | 272.05 | 1391 / 1809 | 10% | 0.24 | 46 / 472 |
| tonsil | 0% | 0 | 0 / 0 | 82% | 8.05 | 37 / 45 |
| heart | 74% | 41.81 | 635 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 66% | 36.33 | 883 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 66% | 33.33 | 528 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 61% | 43.92 | 571 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 17% | 0.20 | 5 / 29 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.02 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006629 | Biological process | lipid metabolic process |
| GO_0008202 | Biological process | steroid metabolic process |
| GO_0042572 | Biological process | retinol metabolic process |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0004745 | Molecular function | all-trans-retinol dehydrogenase (NAD+) activity |
| GO_0047044 | Molecular function | androstan-3-alpha,17-beta-diol dehydrogenase activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0106429 | Molecular function | 11-cis-retinol dehydrogenase |
| GO_0047023 | Molecular function | androsterone dehydrogenase activity |
| GO_0009055 | Molecular function | electron transfer activity |
| Gene name | RDH16 |
| Protein name | Retinol dehydrogenase 16 (EC 1.1.1.105) (EC 1.1.1.209) (EC 1.1.1.315) (EC 1.1.1.53) (Human epidermal retinol dehydrogenase) (hRDH-E) (Microsomal NAD(+)-dependent retinol dehydrogenase 4) (RoDH-4) (Short chain dehydrogenase/reductase family 9C member 8) (Sterol/retinol dehydrogenase) |
| Synonyms | SDR9C8 RODH4 |
| Description | FUNCTION: Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes . Has higher activity towards CRBP-bound retinol than with free retinol . Oxidizes also 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction . . |
| Accessions | ENST00000398138.5 O75452 |
