I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 8 studies | 21% ± 5% | |
| vein endothelial cell | 6 studies | 21% ± 8% | |
| capillary endothelial cell | 3 studies | 17% ± 1% | |
| dendritic cell | 3 studies | 25% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 8 studies | 21% ± 5% | |
| vein endothelial cell | 6 studies | 21% ± 8% | |
| capillary endothelial cell | 3 studies | 17% ± 1% | |
| dendritic cell | 3 studies | 25% ± 7% |
Insufficient scRNA-seq data for expression of RASA4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 93% | 194.55 | 2450 / 2642 | 42% | 0.72 | 299 / 705 |
| adrenal gland | 97% | 233.06 | 249 / 258 | 22% | 0.38 | 51 / 230 |
| kidney | 99% | 375.97 | 88 / 89 | 7% | 0.10 | 61 / 901 |
| breast | 100% | 508.52 | 458 / 459 | 3% | 0.04 | 35 / 1118 |
| thymus | 97% | 291.95 | 635 / 653 | 5% | 0.06 | 29 / 605 |
| bladder | 100% | 379.43 | 21 / 21 | 2% | 0.03 | 10 / 504 |
| uterus | 100% | 628.21 | 170 / 170 | 2% | 0.03 | 9 / 459 |
| ovary | 100% | 351.83 | 180 / 180 | 2% | 0.03 | 7 / 430 |
| muscle | 100% | 1264.12 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 266.00 | 240 / 241 | 0% | 0 | 0 / 0 |
| intestine | 98% | 365.71 | 951 / 966 | 1% | 0.01 | 4 / 527 |
| adipose | 99% | 525.08 | 1194 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 349.71 | 1318 / 1335 | 0% | 0 | 0 / 0 |
| prostate | 98% | 364.07 | 241 / 245 | 0% | 0.00 | 1 / 502 |
| lung | 97% | 324.38 | 558 / 578 | 1% | 0.02 | 14 / 1155 |
| esophagus | 93% | 294.38 | 1342 / 1445 | 3% | 0.05 | 6 / 183 |
| stomach | 89% | 208.10 | 320 / 359 | 1% | 0.02 | 3 / 286 |
| pancreas | 72% | 102.31 | 236 / 328 | 7% | 0.14 | 12 / 178 |
| skin | 76% | 189.53 | 1380 / 1809 | 0% | 0.00 | 1 / 472 |
| heart | 72% | 119.46 | 621 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 41% | 79.46 | 384 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 14% | 0.25 | 4 / 29 |
| liver | 6% | 5.18 | 14 / 226 | 0% | 0 | 0 / 406 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0034260 | Biological process | negative regulation of GTPase activity |
| GO_0046580 | Biological process | negative regulation of Ras protein signal transduction |
| GO_0071277 | Biological process | cellular response to calcium ion |
| GO_0005829 | Cellular component | cytosol |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005543 | Molecular function | phospholipid binding |
| GO_0005096 | Molecular function | GTPase activator activity |
| Gene name | RASA4 |
| Protein name | Ras GTPase-activating protein 4 (Calcium-promoted Ras inactivator) (Ras p21 protein activator 4) (RasGAP-activating-like protein 2) RAS p21 protein activator 4 |
| Synonyms | GAPL CAPRI KIAA0538 |
| Description | FUNCTION: Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. . |
| Accessions | O43374 ENST00000520042.5 ENST00000262940.12 [O43374-1] ENST00000449970.6 [O43374-2] E5RGQ8 E5RID2 Q2NL74 E7ERK1 ENST00000461209.5 H0YB35 ENST00000462172.5 E5RK78 H0YBU2 ENST00000521076.5 ENST00000522801.5 B7ZL55 ENST00000519539.5 ENST00000521397.1 |
