PTPRQ report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PTPRQ at tissue level.

III. Associated gene sets

GO_1990264Biological processpeptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
GO_0045598Biological processregulation of fat cell differentiation
GO_0016324Cellular componentapical plasma membrane
GO_0043235Cellular componentreceptor complex
GO_0120044Cellular componentstereocilium base
GO_0009925Cellular componentbasal plasma membrane
GO_0004725Molecular functionprotein tyrosine phosphatase activity

IV. Literature review

[source]
Gene namePTPRQ
Protein nameProtein tyrosine phosphatase receptor type Q
protein-tyrosine-phosphatase (EC 3.1.3.48)
Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.-) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) (EC 3.1.3.48)
Synonyms
DescriptionFUNCTION: Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells. .

AccessionsA0A087X0B9
F8VW52
F8VXI2
F8W122
ENST00000551042.5
H0YIJ5
ENST00000547881.1
Q9UMZ3
ENST00000644991.3
ENST00000616559.4
ENST00000551573.5
ENST00000547376.5
A0A087WZU1